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Review
. 2021 Aug 4;13(8):1199.
doi: 10.3390/pharmaceutics13081199.

Lipid-Polymeric Films: Composition, Production and Applications in Wound Healing and Skin Repair

Eliana B Souto  1   2 , Cristiana M P Yoshida  3 , Gislaine R Leonardi  4 , Amanda Cano  5   6 , Elena Sanchez-Lopez  5   6 , Aleksandra Zielinska  1   7 , César Viseras  8   9 , Patricia Severino  10   11 , Classius F da Silva  3 , Raquel de M Barbosa  12
Affiliations
Review

Lipid-Polymeric Films: Composition, Production and Applications in Wound Healing and Skin Repair

Eliana B Souto et al. Pharmaceutics. .

Abstract

The use of lipids in the composition of polymeric-based films for topical administration of bioactive ingredients is a recent research topic; while few products are commercially available, films containing lipids represent a strategic area for the development of new products. Some lipids are usually used in polymeric-based film formulations due to their plasticizing action, with a view to improving the mechanical properties of these films. On the other hand, many lipids have healing, antimicrobial, anti-inflammatory, anti-aging properties, among others, that make them even more interesting for application in the medical-pharmaceutical field. This manuscript discusses the production methods of these films both on a laboratory and at industrial scales, the properties of the developed biopolymers, and their advantages for the development of dermatologic and cosmetic products.

Keywords: biopolymers; lipid-polymeric films; lipids; skin repair.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Layers, structures and cells of skin.
Figure 2
Figure 2
Schematic representation of the triacylglycerol molecule structure. Fatty acid is represented by R1 to R3.
Figure 3
Figure 3
Chemical structure of emollients commonly used in cosmetic formulations, (a) Isopropyl myristate; (b) Decyl oleate and (c) Myristyl myristate.
Figure 4
Figure 4
Main points to place facial strips being represented by numbers from 1–5 (a). Facial strips (b).
Figure 5
Figure 5
Schematic representation of the rotor-stator assembly of a high shear homogenizer type of disperser (a) before and after assembly; (b) different types of stators.
Figure 6
Figure 6
Schematic representation of a colloidal mill.
Figure 7
Figure 7
Schematic representation of the continuous emulsification system using ultrasound.
Figure 8
Figure 8
Schematic representation of the experimental system used for the preparation of O/W emulsion using porous glass membrane: (a) membrane; (b) compressed gas; (c) dispersed (oily) phase reservoir; (d) emulsion reservoir and continuous phase (aqueous phase); (e) and—magnetic stirrer; (f) dispersed phase; (g) continuous phase.
Figure 9
Figure 9
Schematic of the high-pressure valve homogenizer used to prepare emulsion with reduced size of particles.
Figure 10
Figure 10
Schematic representation of the front (a) and cross (b) sections of a film production machine using the solvent spreading and evaporation technique: (1) air inlet; (2) air outlet; (3) external container; (4′) inner drum; (4′’) pulleys; and polymer spreader; (5) removed film; (6) roller; (7) moving belt.
Figure 11
Figure 11
Illustration of the extrusion-spreading machine to film production.
See this image and copyright information in PMC

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