SHARED: An International Collaboration to Unravel Hepatitis C Resistance
- PMID: 34452444
- PMCID: PMC8402898
- DOI: 10.3390/v13081580
SHARED: An International Collaboration to Unravel Hepatitis C Resistance
Abstract
The advent of direct-acting antivirals (DAAs) has transformed the treatment landscape of hepatitis C [...].
Conflict of interest statement
J.M.P. has been an advisor and/or speaker for Abbvie, Assembly Biosciences, Arbutus, Merck, Gilead, Regulus and Memo Therapeutics. J.D. receives research support from Gilead. A.Y.M.H. is a consultant for Boston Pharmaceuticals. J.G. reports grants and personal fees from Abbvie, Gilead Sciences, Merck, and Cepheid and grants from Hologic and Indivior, outside the submitted work.
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References
-
- Forns X., Lee S.S., Valdes J., Lens S., Ghalib R., Aguilar H., Felizarta F., Hassanein T., Hinrichsen H., Rincon D., et al. Glecaprevir plus pibrentasvir for chronic hepatitis C virus genotype 1, 2, 4, 5, or 6 infection in adults with compensated cirrhosis (EXPEDITION-1): A single-arm, open-label, multicentre phase 3 trial. Lancet Infect. Dis. 2017;17:1062–1068. doi: 10.1016/S1473-3099(17)30496-6. - DOI - PubMed
-
- World Health Organization . The Draft WHO Global Hepatitis Strategy. World Health Organization; Geneva, Switzerland: 2016. Towards the elimination of hepatitis B and C by 2030.
-
- Kwo P., Gitlin N., Nahass R., Bernstein D., Rojter S., Schiff E., Davis M., Ruane P.J., Younes Z., Kalmeijer R. A phase 3, randomised, open-label study to evaluate the efficacy and safety of 8 and 12 weeks of simeprevir (SMV) plus sofosbuvir (SOF) in treatment-naive and-experienced patients with chronic HCV genotype 1 infection without cirrhosis: OPTIMIST-1. J. Hepatol. 2015;62:S270. doi: 10.1016/S0168-8278(15)30168-9. - DOI