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. 2021 Aug 23;13(8):1671.
doi: 10.3390/v13081671.

Congenital Zika Infection and the Risk of Neurodevelopmental, Neurological, and Urinary Track Disorders in Early Childhood. A Systematic Review

Evangelia Antoniou  1 , Eirini Orovou  1 , Paraskevi Eva Andronikidi  2 , Christos Orovas  3 , Nikolaos Rigas  1 , Ermioni Palaska  1 , Angeliki Sarella  1 , Georgios Iatrakis  1 , Chrysa Voyiatzaki  4
Affiliations

Congenital Zika Infection and the Risk of Neurodevelopmental, Neurological, and Urinary Track Disorders in Early Childhood. A Systematic Review

Evangelia Antoniou et al. Viruses. .

Abstract

It was late 2015 when Northeast Brazil noticed a worrying increase in neonates born with microcephaly and other congenital malformations. These abnormalities, characterized by an abnormally small head and often neurological impairment and later termed Congenital Zika Syndrome, describe the severity of neurodevelopmental and nephrological outcomes in early childhood, and the implication of microcephaly at birth. The purpose of the study was to describe the neurodevelopmental outcomes in children exposed to Zika virus during fetal life, with and without microcephaly at birth. The systematic review included research studies about the neurodevelopmental outcomes with and without microcephaly, as well as nephrological outcomes in early childhood. We searched PubMed, Crossref, PsycINFO, Scopus, and Google Scholar publications and selected 19 research articles published from 2018 to 2021. Most studies have linked the severity of microcephaly in childbirth to the neurodevelopmental and urinary outcomes in early childhood. However, most children without microcephaly at birth develop typically, while others may be at risk for language impairment.

Keywords: Zika virus infection; congenital Zika infection and neurodevelopment outcomes; congenital Zika infection and neurological outcomes; congenital Zika infection and urinary tract disorders; congenital Zika syndrome.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow chart-Structure Search Strategy.
Figure 2
Figure 2
Neurological, neurodevelopmental, and urinary track outcomes in intrauterine exposed to Zika virus children.
See this image and copyright information in PMC

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