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. 2021:92:151-190.
doi: 10.1016/bs.apha.2021.03.008. Epub 2021 May 3.

Endocrine disrupting chemicals and reproductive disorders in women, men, and animal models

Mary Jo Laws  1 , Alison M Neff  1 , Emily Brehm  1 , Genoa R Warner  1 , Jodi A Flaws  2
Affiliations

Endocrine disrupting chemicals and reproductive disorders in women, men, and animal models

Mary Jo Laws et al. Adv Pharmacol. 2021.

Abstract

This chapter covers the known effects of endocrine disrupting chemicals (EDCs) on reproductive disorders. The EDCs represented are highly studied, including plasticizers (bisphenols and phthalates), chemicals in personal care products (parabens), persistent environmental contaminants (polychlorinated biphenyls), and chemicals in pesticides or herbicides. Both female and male reproductive disorders are reviewed in the chapter. Female disorders include infertility/subfertility, irregular reproductive cycles, early menopause, premature ovarian insufficiency, polycystic ovarian syndrome, endometriosis, and uterine fibroids. Male disorders include infertility/subfertility, cryptorchidism, and hypospadias. Findings from both human and animal studies are represented.

Keywords: Bisphenol; Endocrine disrupting chemical; Fertility; Paraben; Perfluorochemical; Pesticides; Phthalate; Polychlorinated biphenyls; Reproduction; Reproductive system health.

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Conflict of interest statement

Conflict of interest statement

The authors have no conflicts of interest.

Figures

Fig. 1
Fig. 1
A summary of EDCs associated with female reproductive disorders.
Fig. 2
Fig. 2
A summary of EDCs associated with male reproductive disorders.
See this image and copyright information in PMC

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