Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Aug 27;23(11):130.
doi: 10.1007/s11912-021-01118-7.

Prostate Cancer in Older Adults: Risk of Clinically Meaningful Disease, the Role of Screening and Special Considerations

Tyler P Robin  1 , Christopher L Geiger  2 , Eryn B Callihan  2 , Elizabeth R Kessler  2
Affiliations
Review

Prostate Cancer in Older Adults: Risk of Clinically Meaningful Disease, the Role of Screening and Special Considerations

Tyler P Robin et al. Curr Oncol Rep. .

Abstract

Purpose of review: Prostate cancer is the second most common cancer in men in the USA and several studies suggest more aggressive disease in older patients. However, screening remains controversial, especially in the older patient population.

Recent findings: Aggressive prostate cancers are more common in older men. Screening trial results are conflicting but data suggest an improvement in prostate cancer mortality and increased detection of metastatic disease with screening. When PSA is utilized with multiparametric MRI and biomarker assays, patients at significant risk of clinically meaningful prostate cancer can be appropriately selected for biopsy. A thoughtful and individualized approach is central when considering prostate cancer screening in older men. This approach includes life expectancy estimation, use of appropriate geriatric assessment tools, use of multiparametric MRI and biomarkers in addition to PSA, and most importantly shared decision-making with patients.

Keywords: 4Kscore; Biomarkers; Clinically significant prostate cancer; Comprehensive geriatric assessment; ExoDx; Geriatric oncology; MRI; Multiparametric MRI; PSA; Phi; Prostate cancer; Screening; Select MDX.

PubMed Disclaimer

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
    1. Cancer Stat Facts: Prostate Cancer. Available from: https://seer.cancer.gov/statfacts/html/prost.html .
    1. Howlader N, N.A., Krapcho M, Miller D, Brest A, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds), SEER cancer statistics review, 1975–2017. April 2020.
    1. Grossman DC, et al. Screening for prostate cancer: US Preventive Services Task Force recommendation statement. JAMA. 2018;319(18):1901–13. - DOI
    1. Social Security Actuarial Life Table. [cited 2021; Available from: https://www.ssa.gov/OACT/STATS/table4c6.html .
    1. World Health Organization Life Tables by Country. [cited 2021; Available from: https://apps.who.int/gho/data/view.main.60000?lang=en .

Substances

LinkOut - more resources