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Review
. 2021:1331:277-287.
doi: 10.1007/978-3-030-74046-7_19.

Nerve Growth Factor (NGF) and Animal Reproduction

Margherita Maranesi  1 , Cristiano Boiti  2 , Massimo Zerani  2
Affiliations
Review

Nerve Growth Factor (NGF) and Animal Reproduction

Margherita Maranesi et al. Adv Exp Med Biol. 2021.

Abstract

Stimuli that lead to the release of gonadotropin-releasing hormone (GnRH) and pituitary gonadotropins and, consequently, ovulation in mammals fall into two broad categories. In the first, high plasma oestrogen concentrations induce the events that trigger ovulation, a characteristic of spontaneous ovulators. In the second, nerve stimuli occurring during mating reach the hypothalamus and trigger the release of GnRH and ovulation with a neuroendocrine reflex that characterizes induced ovulators.In this review, we will give an overview of the distribution of NGF and its expression in the different tissues of the male accessory sex glands, the main sites of NGF production. Next, we will highlight the role of NGF in sperm function and its potential cryopreserving role in artificial insemination techniques. Finally, we will evaluate the functions of NGF in ovulation, particularly in induced ovulators. Overall, the information obtained so far indicates that NGF is widely distributed in organs that regulate the reproductive activity, in both males and females. In spontaneous ovulators, NGF exerts mainly a luteotrophic action, while, in induced ovulators it is the main ovulation-inducing factor. A better understanding of the role of NGF in reproduction would be of great interest, since it could help finding innovative therapeutic aids to improve mammalian fertility.

Keywords: Growth factors; Ovary; Ovulation; Pituitary; Seminal plasma; Sperm; Uterus.

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References

    1. Adams GP, Ratto MH, Huanca W, Singh J (2005) Ovulation-inducing factor in the seminal plasma of alpacas and llamas. Biol Reprod 73(3):452–457 - PubMed - DOI - PMC
    1. Adams GP, Ratto MH, Silva ME, Carrasco RA (2016) Ovulation-inducing factor (OIF/NGF) in seminal plasma: a review and update. Reprod Dom Anim 51:4–17 - DOI
    1. Aurich C, Schreiner B, Ille N, Alvarenga M, Scarlet D (2016) Cytosine methylation of sperm DNA in horse semen after cryopreservation. Theriogenology 86(5):1347–1352 - PubMed - DOI
    1. Bakker J, Baum MJ (2000) Neuroendocrine regulation of GnRH release in induce ovulators. Front Neuroendocrinol 21:220–262 - PubMed - DOI
    1. Berland MA, Ulloa-Leal C, Barría M, Wright H, Dissen GA, Silva ME et al (2016) Seminal plasma induces ovulation in llamas in the absence of a copulatory stimulus: role of nerve growth factor as an ovulation-inducing factor 1. Endocrinology 57(8):3224–3232 - DOI

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