International consensus on the use of [¹⁸F]-FDG PET/CT in pediatric patients affected by epilepsy

Mei Tian^{1

2}, Yasuyoshi Watanabe³, Keon Wook Kang⁴, Koji Murakami⁵, Arturo Chiti^{6

7}, Ignasi Carrio⁸, A Cahid Civelek⁹, Jianhua Feng¹⁰, Yuankai Zhu^{11

12}, Rui Zhou^{11

12}, Shuang Wu^{11

12}, Junming Zhu¹³, Yao Ding¹⁴, Kai Zhang³, Hong Zhang^{15

16

17

18}; Molecular Imaging-based Precision Medicine Task Group of A3 (China-Japan-Korea) Foresight Program

Affiliations

¹ Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China. meitian@zju.edu.cn.
² Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, 310009, China. meitian@zju.edu.cn.
³ Laboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo, 650-0047, Japan.
⁴ Department of Nuclear Medicine, Seoul National University Hospital, Seoul, 03080, Korea.
⁵ Department of Radiology, Juntendo University Hospital, Tokyo, 113-8431, Japan.
⁶ Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Milan, Italy.
⁷ IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy.
⁸ Department of Nuclear Medicine, Hospital Sant Pau, Autonomous University of Barcelona, 08025, Barcelona, Spain.
⁹ Department of Radiology and Radiological Science, Johns Hopkins Medicine, Baltimore, MD, 21287, USA.
¹⁰ Department of Pediatrics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China.
¹¹ Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.
¹² Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, 310009, China.
¹³ Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China.
¹⁴ Department of Neurology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China.
¹⁵ Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China. hzhang21@zju.edu.cn.
¹⁶ Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, 310009, China. hzhang21@zju.edu.cn.
¹⁷ The College of Biomedical Engineering and Instrument Science of Zhejiang University, Hangzhou, 310007, China. hzhang21@zju.edu.cn.
¹⁸ Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, 310007, China. hzhang21@zju.edu.cn.

PMID: 34453559
DOI: 10.1007/s00259-021-05524-8

International consensus on the use of [¹⁸F]-FDG PET/CT in pediatric patients affected by epilepsy

Mei Tian et al. Eur J Nucl Med Mol Imaging. 2021 Nov.

. 2021 Nov;48(12):3827-3834.

doi: 10.1007/s00259-021-05524-8. Epub 2021 Aug 28.

Authors

Affiliations

¹ Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China. meitian@zju.edu.cn.
² Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, 310009, China. meitian@zju.edu.cn.
³ Laboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo, 650-0047, Japan.
⁴ Department of Nuclear Medicine, Seoul National University Hospital, Seoul, 03080, Korea.
⁵ Department of Radiology, Juntendo University Hospital, Tokyo, 113-8431, Japan.
⁶ Department of Biomedical Sciences, Humanitas University, 20090 Pieve Emanuele, Milan, Italy.
⁷ IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089, Rozzano, Milan, Italy.
⁸ Department of Nuclear Medicine, Hospital Sant Pau, Autonomous University of Barcelona, 08025, Barcelona, Spain.
⁹ Department of Radiology and Radiological Science, Johns Hopkins Medicine, Baltimore, MD, 21287, USA.
¹⁰ Department of Pediatrics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China.
¹¹ Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.
¹² Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, 310009, China.
¹³ Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China.
¹⁴ Department of Neurology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China.
¹⁵ Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China. hzhang21@zju.edu.cn.
¹⁶ Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, 310009, China. hzhang21@zju.edu.cn.
¹⁷ The College of Biomedical Engineering and Instrument Science of Zhejiang University, Hangzhou, 310007, China. hzhang21@zju.edu.cn.
¹⁸ Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, 310007, China. hzhang21@zju.edu.cn.

PMID: 34453559
DOI: 10.1007/s00259-021-05524-8

Abstract

Purpose: Positron emission tomography (PET) with ¹⁸F-fluorodeoxyglucose ([¹⁸F]-FDG) has been increasingly applied in precise localization of epileptogenic focus in epilepsy patients, including pediatric patients. The aim of this international consensus is to provide the guideline and specific considerations for [¹⁸F]-FDG PET in pediatric patients affected by epilepsy.

Methods: An international, multidisciplinary task group is formed, and the guideline for brain [¹⁸F]-FDG PET/CT in pediatric epilepsy patients has been discussed and approved, which include but not limited to the clinical indications, patient preparation, radiopharmaceuticals and administered activities, image acquisition, image processing, image interpretation, documentation and reporting, etc. CONCLUSION: This is the first international consensus and practice guideline for brain [¹⁸F]-FDG PET/CT in pediatric epilepsy patients. It will be an international standard for this purpose in clinical practice.

Keywords: Brain imaging; Epilepsy; FDG; PET/CT; Pediatric patients.

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References

1. Collaborators GE. Global, regional, and national burden of epilepsy, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18:357–75. https://doi.org/10.1016/s1474-4422(18)30454-x . - DOI
1. Rosati A, De Masi S, Guerrini R. Antiepileptic drug treatment in children with epilepsy. CNS Drugs. 2015;29:847–63. https://doi.org/10.1007/s40263-015-0281-8 . - DOI - PubMed - PMC
1. Witt JA, Elger CE, Helmstaedter C. Adverse cognitive effects of antiepileptic pharmacotherapy: each additional drug matters. Eur Neuropsychopharmacol. 2015;25:1954–9. https://doi.org/10.1016/j.euroneuro.2015.07.027 . - DOI - PubMed
1. Dwivedi R, Ramanujam B, Chandra P, Sapra S, Gulati S, Kalaivani M, et al. Surgery for drug-resistant epilepsy in children. N Engl J Med. 2017;377:1639–47. https://doi.org/10.1056/NEJMoa1615335 . - DOI - PubMed
1. Zhang M, Liu W, Huang P, Lin X, Huang X, Meng H, et al. Utility of hybrid PET/MRI multiparametric imaging in navigating SEEG placement in refractory epilepsy. Seizure. 2020;81:295–303. https://doi.org/10.1016/j.seizure.2020.08.027 . - DOI - PubMed

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International consensus on the use of [¹⁸F]-FDG PET/CT in pediatric patients affected by epilepsy

Affiliations

International consensus on the use of [¹⁸F]-FDG PET/CT in pediatric patients affected by epilepsy

Authors

Affiliations

Abstract

References

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Medical