Clinical implications of alpha, beta, and gamma HPV infection in juvenile onset recurrent respiratory papillomatosis

doi:10.1007/s00405-021-07040-9

Observational Study

. 2022 Jan;279(1):285-292.

doi: 10.1007/s00405-021-07040-9. Epub 2021 Aug 28.

Clinical implications of alpha, beta, and gamma HPV infection in juvenile onset recurrent respiratory papillomatosis

Affiliations

¹ Department of Neurosciences, Section of Otolaryngology, University of Padova, Padova, Italy.
² International Agency for Research On Cancer, Lyon, France.
³ Unit of Cancer Epidemiology, Centro Di Riferimento Oncologico Di Aviano (CRO) IRCCS, Aviano, Italy.
⁴ Department of Medicine, Section of Pathology, University of Padova, Padova, Italy.
⁵ Department of Neurosciences, Section of Otolaryngology, University of Padova, Padova, Italy. paolo.boscolorizzo@units.it.
⁶ Department of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Strada di Fiume 447, 34149, Trieste, Italy. paolo.boscolorizzo@units.it.

PMID: 34453571
PMCID: PMC8738360
DOI: 10.1007/s00405-021-07040-9

Observational Study

Clinical implications of alpha, beta, and gamma HPV infection in juvenile onset recurrent respiratory papillomatosis

Martina Bertinazzi et al. Eur Arch Otorhinolaryngol. 2022 Jan.

. 2022 Jan;279(1):285-292.

doi: 10.1007/s00405-021-07040-9. Epub 2021 Aug 28.

Affiliations

¹ Department of Neurosciences, Section of Otolaryngology, University of Padova, Padova, Italy.
² International Agency for Research On Cancer, Lyon, France.
³ Unit of Cancer Epidemiology, Centro Di Riferimento Oncologico Di Aviano (CRO) IRCCS, Aviano, Italy.
⁴ Department of Medicine, Section of Pathology, University of Padova, Padova, Italy.
⁵ Department of Neurosciences, Section of Otolaryngology, University of Padova, Padova, Italy. paolo.boscolorizzo@units.it.
⁶ Department of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Strada di Fiume 447, 34149, Trieste, Italy. paolo.boscolorizzo@units.it.

PMID: 34453571
PMCID: PMC8738360
DOI: 10.1007/s00405-021-07040-9

Abstract

Purpose: The aim of our study was to evaluate the prevalence of different HPV genera-alpha, beta and gamma-in Juvenile onset Recurrent Respiratory Papillomatosis (JoRRP) and examine the association of type and genus-specific viral features with the clinical outcome of disease.

Methods: This retrospective observational study included consecutive patients with JoRRP who were treated in a referral centre between October 2000 and October 2020. All patients underwent cold excision and laser vaporisation of papillomatous lesions. Samples were analysed for the presence of 120 viral genotypes (22 alpha-HPV, 46 beta-HPV, 52 gamma-HPV) using a highly sensitive multiplex genotyping assay.

Results: Twenty patients with JoRRP, aged 0.3-11 years, were included, with a median follow-up of 13.5 years. All samples were HPV DNA positive: 20 (100%) for alpha-HPV DNA; 7 (35%) for beta-HPV DNA; 0 for gamma-HPV DNA. Three groups were defined according to the number of infections: seven cases (35%) with HPV mono-infection; ten cases (50%) with HPV double-infection; three cases (15%) with ≥ 3 HPV infections. At diagnosis, patients with ≥ 3 HPV infections reported higher median Derkay's score than those with mono-infection (21 vs 14, P = 0.018). Number of HPV infections was also associated with clinical outcomes, with an average of 0.5 surgical procedures/year in patients with mono-infection, 1.2 for double-infection, 2.6 for ≥ 3 infections (P = 0.006).

Conclusion: Despite the small sample size, these preliminary data support an association between the number of different alpha and beta HPV co-infections and the clinical severity of the disease.

Keywords: Children; Co-infections; Human papillomavirus; Juvenile respiratory papillomatosis; Prognosis.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflict of interests to declare that are relevant to the content of this article.

Figures

**Fig. 1**
Cumulative number of surgeries according to number of co-infection with *alpha*-HPV and with *beta*-HPV

**Fig. 2**
Cumulative number of surgeries according to *alpha*-HPV infections

See this image and copyright information in PMC

Cited by

"A systematic literature review of the epidemiology, clinical, economic and humanistic burden in recurrent respiratory papillomatosis".
Ovcinnikova O, Engelbrecht K, Verma M, Pandey R, Morais E. Ovcinnikova O, et al. Respir Res. 2024 Dec 18;25(1):430. doi: 10.1186/s12931-024-03057-w. Respir Res. 2024. PMID: 39696284 Free PMC article.
Analysis of the anatomical distribution of HPV genotypes in head and neck squamous papillomas.
Hu H, Jiang H, Zhu Z, Yin H, Liu K, Chen L, Zhao M, Yu Z. Hu H, et al. PLoS One. 2023 Aug 11;18(8):e0290004. doi: 10.1371/journal.pone.0290004. eCollection 2023. PLoS One. 2023. PMID: 37566623 Free PMC article.
Broad-Spectrum Detection of HPV in Male Genital Samples Using Target-Enriched Whole-Genome Sequencing.
Li T, Unger ER, Rajeevan MS. Li T, et al. Viruses. 2023 Sep 21;15(9):1967. doi: 10.3390/v15091967. Viruses. 2023. PMID: 37766373 Free PMC article.
HPV-related diseases in male patients: an underestimated conundrum.
Garolla A, Graziani A, Grande G, Ortolani C, Ferlin A. Garolla A, et al. J Endocrinol Invest. 2024 Feb;47(2):261-274. doi: 10.1007/s40618-023-02192-3. Epub 2023 Sep 28. J Endocrinol Invest. 2024. PMID: 37770654 Free PMC article. Review.

References

1. Buchinsky FJ, Valentino WL, Ruszakay N, et al. Age at diagnosis, but not HPV type, is strongly associated with clinical course in recurrent respiratory papilllomatosis. PLoS ONE. 2019;14(6):e0216697. doi: 10.1371/journal.pone.0216697. - DOI - PMC - PubMed
1. Costa V, El-Achkar V, de Barros P, et al. Role of Epstein-Barr virus in the severity of recurrent respiratory papillomatosis. Laryngoscope. 2020 doi: 10.1002/lary.28465. - DOI - PubMed
1. Mammas IN, Dalianis T, Doukas SG, et al. Paediatric virology and human papillomaviruses: an update. Exp Ther Med. 2019;17:4337–4343. doi: 10.3892/etm.2019.7516. - DOI - PMC - PubMed
1. Ribeiro Fortes H, Mussi von Ranke F, Escuissato DL, et al. Recurrent respiratory papillomatosis: a state-of-the-art review. Respir Med. 2017;126:116–121. doi: 10.1016/j.rmed.2017.03.030. - DOI - PubMed
1. Ryan MA, Leu GR, Upchurch PA, et al. Systemic bevacizumab (Avastin) for juvenile-onset recurrent respiratory papillomatosis: a systematic review. Laryngoscope. 2021;131(5):1138–1146. doi: 10.1002/lary.29084. - DOI - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Supplementary concepts

Actions

Grants and funding

001/WHO_/World Health Organization/International

LinkOut - more resources

Full Text Sources

[1] Buchinsky FJ, Valentino WL, Ruszakay N, et al. Age at diagnosis, but not HPV type, is strongly associated with clinical course in recurrent respiratory papilllomatosis. PLoS ONE. 2019;14(6):e0216697. doi: 10.1371/journal.pone.0216697. - DOI - PMC - PubMed

[2] Buchinsky FJ, Valentino WL, Ruszakay N, et al. Age at diagnosis, but not HPV type, is strongly associated with clinical course in recurrent respiratory papilllomatosis. PLoS ONE. 2019;14(6):e0216697. doi: 10.1371/journal.pone.0216697. - DOI - PMC - PubMed

[3] Costa V, El-Achkar V, de Barros P, et al. Role of Epstein-Barr virus in the severity of recurrent respiratory papillomatosis. Laryngoscope. 2020 doi: 10.1002/lary.28465. - DOI - PubMed

[4] Costa V, El-Achkar V, de Barros P, et al. Role of Epstein-Barr virus in the severity of recurrent respiratory papillomatosis. Laryngoscope. 2020 doi: 10.1002/lary.28465. - DOI - PubMed

[5] Mammas IN, Dalianis T, Doukas SG, et al. Paediatric virology and human papillomaviruses: an update. Exp Ther Med. 2019;17:4337–4343. doi: 10.3892/etm.2019.7516. - DOI - PMC - PubMed

[6] Mammas IN, Dalianis T, Doukas SG, et al. Paediatric virology and human papillomaviruses: an update. Exp Ther Med. 2019;17:4337–4343. doi: 10.3892/etm.2019.7516. - DOI - PMC - PubMed

[7] Ribeiro Fortes H, Mussi von Ranke F, Escuissato DL, et al. Recurrent respiratory papillomatosis: a state-of-the-art review. Respir Med. 2017;126:116–121. doi: 10.1016/j.rmed.2017.03.030. - DOI - PubMed

[8] Ribeiro Fortes H, Mussi von Ranke F, Escuissato DL, et al. Recurrent respiratory papillomatosis: a state-of-the-art review. Respir Med. 2017;126:116–121. doi: 10.1016/j.rmed.2017.03.030. - DOI - PubMed

[9] Ryan MA, Leu GR, Upchurch PA, et al. Systemic bevacizumab (Avastin) for juvenile-onset recurrent respiratory papillomatosis: a systematic review. Laryngoscope. 2021;131(5):1138–1146. doi: 10.1002/lary.29084. - DOI - PubMed

[10] Ryan MA, Leu GR, Upchurch PA, et al. Systemic bevacizumab (Avastin) for juvenile-onset recurrent respiratory papillomatosis: a systematic review. Laryngoscope. 2021;131(5):1138–1146. doi: 10.1002/lary.29084. - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Clinical implications of alpha, beta, and gamma HPV infection in juvenile onset recurrent respiratory papillomatosis

Affiliations

Clinical implications of alpha, beta, and gamma HPV infection in juvenile onset recurrent respiratory papillomatosis

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Supplementary concepts

Grants and funding

LinkOut - more resources

Full Text Sources

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Supplementary concepts

Related information

Grants and funding

LinkOut - more resources

Full Text Sources