Role of calcium oscillations in sperm physiology

Abstract

Intracellular Ca²⁺ is a key regulator of cell signaling and sperm are not the exception. Cells often use cytoplasmic Ca²⁺ concentration ([Ca²⁺]_i) oscillations as a means to decodify external and internal information. [Ca²⁺]_i oscillations faster than those usually found in other cells and correlated with flagellar beat were the first to be described in sperm in 1993 by Susan Suarez, in the boar. More than 20 years passed before similar [Ca²⁺]_i oscillations were documented in human sperm, simultaneously examining their flagellar beat in three dimensions by Corkidi et al. 2017. On the other hand, 10 years after the discovery of the fast boar [Ca²⁺]_i oscillations, slower ones triggered by compounds from the egg external envelope were found to regulate cell motility and chemotaxis in sperm from marine organisms. Today it is known that sperm display fast and slow spontaneous and agonist triggered [Ca²⁺]_i oscillations. In mammalian sperm these Ca²⁺ transients may act like a multifaceted tool that regulates fundamental functions such as motility and acrosome reaction. This review covers the main sperm species and experimental conditions where [Ca²⁺]_i oscillations have been described and discusses what is known about the transporters involved, their regulation and the physiological purpose of these oscillations. There is a lot to be learned regarding the origin, regulation and physiological relevance of these Ca²⁺ oscillations.

Keywords: Acrosome reaction; Capacitation; Intracellular Ca(2+); Motility; Sperm physiology.