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. 2021 Aug 28;40(1):11.
doi: 10.1186/s40101-021-00259-9.

Association of rs9939609-FTO with metabolic syndrome components among women from Mayan communities of Chiapas, Mexico

Pilar E Núñez Ortega  1 , María E Meneses  2 , Iván Delgado-Enciso  3   4 , César Antonio Irecta-Nájera  5 , Itandehui Castro-Quezada  1 , Roberto Solís-Hernández  1 , Elena Flores-Guillén  6 , Rosario García-Miranda  1   7 , Adán Valladares-Salgado  8 , Daniel Locia-Morales  8 , Héctor Ochoa-Díaz-López  9
Affiliations

Association of rs9939609-FTO with metabolic syndrome components among women from Mayan communities of Chiapas, Mexico

Pilar E Núñez Ortega et al. J Physiol Anthropol. .

Abstract

Background: Metabolic syndrome (MetS) is a complex cluster of risk factors, considered as a polygenic and multifactorial entity. The objective of this study was to determine the association of rs9939609-FTO polymorphism and MetS components in adult women of Mayan communities of Chiapas.

Methods: In a cross-sectional study, sociodemographic, anthropometric, clinical, and biochemical data were obtained from 291 adult women from three regions of Chiapas, Mexico. The prevalence of MetS and the allele and genotype frequencies of the rs9939609-FTO were estimated. Multivariate logistic regression models were used to assess the association of the single nucleotide polymorphism (SNP) with each of the MetS components.

Results: The MetS prevalence was 60%. We found a statistically significant association between rs9939609-FTO and hyperglycemia in the dominant model (OR 2.6; 95% CI 1.3-5.3; p = 0.007).

Conclusions: Women from Mayan communities of Chiapas presented a high prevalence of MetS and a relevant association of the FTO variant with hyperglycemia. This is the first study carried out in these Mayan indigenous communities from Chiapas.

Keywords: Chiapas; FTO; Mayan indigenous women; Metabolic syndrome; Mexico; Single nucleotide polymorphisms.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Study area: Tzotzil-Tzeltal, Selva, and Soconusco regions of Chiapas, Mexico
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References

    1. Córdova-Villalobos J, Meléndez J, Lara-Esqueda A, et al. Chronic non-communicable diseases in Mexico: epidemiologic synopsis and integral prevention. Salud Pública Méx. 2008;50:419–427. doi: 10.1590/S0036-36342008000500015. - DOI - PubMed
    1. De Fronzo R, Ferrannini E. Insulin resistance: a multifocal syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia and atherosclerotic cardiovascular disease. Diabetes Care. 1991;14:173–194. doi: 10.2337/diacare.14.3.173. - DOI - PubMed
    1. Stern M. The insulin resistance syndrome: the controversy is dead, long live the controversy. Diabetologia. 1994;37:956–958. doi: 10.1007/BF00400955. - DOI - PubMed
    1. Isomma B, Almgren P, Tuomi T, et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care. 2001;24:683–689. doi: 10.2337/diacare.24.4.683. - DOI - PubMed
    1. Groop L. Genetics of the metabolic syndrome. Br J Nutr. 2000;83:39–48. doi: 10.1017/s0007114500000945. - DOI - PubMed

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