Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2021 Dec;225(6):689-693.e1.
doi: 10.1016/j.ajog.2021.08.020. Epub 2021 Aug 26.

SARS-CoV-2 and the subsequent development of preeclampsia and preterm birth: evidence of a dose-response relationship supporting causality

Jonathan Lai  1 , Roberto Romero  2 , Adi L Tarca  3 , Stamatina Iliodromiti  4 , Anoop Rehal  5 , Anita Banerjee  6 , Christina Yu  7 , Gergana Peeva  8 , Vadivu Palaniappan  9 , Linda Tan  10 , Mahishee Mehta  11 , Kypros H Nicolaides  1
Affiliations
Observational Study

SARS-CoV-2 and the subsequent development of preeclampsia and preterm birth: evidence of a dose-response relationship supporting causality

Jonathan Lai et al. Am J Obstet Gynecol. 2021 Dec.
No abstract available

PubMed Disclaimer

Figures

Figure
Figure
Association between SARS-CoV-2 infection severity and pregnancy outcomes A, Expected and observed rates of preeclampsia in women with SARS-CoV-2 infection. B, Observed rates of preterm birth in women with SARS-CoV-2 infection who had a live neonate. C, Gestational age at delivery in women with SARS-CoV-2 infection who had a live neonate. D, Rate of moderate, very, and extreme preterm birth as a function of the severity of SARS-CoV-2 infection. Lai. SARS-CoV-2, preeclampsia, and preterm birth. Am J Obstet Gynecol 2021.
See this image and copyright information in PMC

References

    1. Mendoza M., Garcia-Ruiz I., Maiz N., et al. Pre-eclampsia-like syndrome induced by severe COVID-19: a prospective observational study. BJOG. 2020;127:1374–1380. - PMC - PubMed
    1. Metz T.D., Clifton R.G., Hughes B.L., et al. Disease severity and perinatal outcomes of pregnant patients with coronavirus disease 2019 (COVID-19) Obstet Gynecol. 2021;137:571–580. - PMC - PubMed
    1. Conde-Agudelo A., Romero R. SARS-COV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis. Am J Obstet Gynecol. 2021 [Epub ahead of print] - PMC - PubMed
    1. Wright D., Syngelaki A., Akolekar R., Poon L.C., Nicolaides K.H. Competing risks model in screening for preeclampsia by maternal characteristics and medical history. Am J Obstet Gynecol. 2015;213:62.e1–62.e10. - PubMed
    1. Papageorghiou A.T., Deruelle P., Gunier R.B., et al. Preeclampsia and COVID-19: results from the INTERCOVID prospective longitudinal study. Am J Obstet Gynecol. 2021;225:289.e1–289.e17. - PMC - PubMed