Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Dec 1;42(12):1293-1300.
doi: 10.1097/MNM.0000000000001481.

18F-FDG PET and PET/CT for the evaluation of gastric signet ring cell carcinoma: a systematic review

Francesco Dondi  1 , Domenico Albano, Raffaele Giubbini, Francesco Bertagna
Affiliations

18F-FDG PET and PET/CT for the evaluation of gastric signet ring cell carcinoma: a systematic review

Francesco Dondi et al. Nucl Med Commun. .

Abstract

Background: In the last years, 18F-fluorodeoxyglucose PET/computed tomography (18F-FDG PET/CT) has demonstrated its utility for the evaluation of gastric cancer; however, considering some histotypes such as gastric signet ring cell carcinoma (GSRCC) the results are limited. The aim of this review is to analyze the diagnostic performance of 18F-FDG PET and PET/CT for the assessment of GSRCC.

Methods: A wide literature search of the PubMed/MEDLINE, Scopus, Embase and Cochrane library databases was made to find relevant published articles about the diagnostic performance of 18F-FDG PET or PET/CT for the evaluation of GSRCC.

Results: The comprehensive computer literature search revealed 179 articles. On reviewing the titles and abstracts, 162 articles were excluded because the reported data were not within the field of interest. Nine studies were included in the review and references were also screened for additional articles. Finally, 26 articles were selected and retrieved in full-text version.

Conclusion: Despite some limitations affect our review, GSRCC seems to have low 18F-FDG uptake, and therefore 18F-FDG PET or PET/CT reveals impaired sensitivity for its evaluation. However, a correlation between 18F-FDG uptake and some clinico-pathologic features (such as stage, depth of invasion, size and presence of nodal metastasis) has been demonstrated. Besides, a possible prognostic role of PET/CT features is starting to emerge.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Flow chart of the search of eligible studies on the diagnostic performance of 18F-FDG PET or PET/CT for the assessment of GSRCC.
Fig. 2
Fig. 2
QUADAS-2 quality assessment for risk of bias (2a) and applicability concerns (2b). QUADAS, Quality Assessment of Diagnostic Accuracy Studies.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Kaneko Y, Murray WK, Link E, Hicks RJ, Duong C. Improving patient selection for 18F-FDG PET scanning in the staging of gastric cancer. J Nucl Med. 2015; 56:523–529. - PubMed
    1. Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 2006; 24:2137–2150. - PubMed
    1. Berlth F, Bollschweiler E, Drebber U, Hoelscher AH, Moenig S. Pathohistological classification systems in gastric cancer: diagnostic relevance and prognostic value. World J Gastroenterol. 2014; 20:5679–5684. - PMC - PubMed
    1. Kunisaki C, Makino H, Akiyama H, Otsuka Y, Ono HA, Kosaka T, et al. . Clinical significance of the metastatic lymph-node ratio in early gastric cancer. J Gastrointest Surg. 2008; 12:542–549. - PubMed
    1. Bilici A, Ustaalioglu BB, Seker M, Kefeli U, Canpolat N, Tekinsoy B, et al. . The role of 18F-FDG PET/CT in the assessment of suspected recurrent gastric cancer after initial surgical resection: can the results of FDG PET/CT influence patients’ treatment decision making? Eur J Nucl Med Mol Imaging. 2011; 38:64–73. - PubMed

Publication types

MeSH terms

Substances