Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Aug 15;13(8):822-834.
doi: 10.4251/wjgo.v13.i8.822.

Reflectance spectra analysis for mucous assessment

Toru Chiba  1 , Masaharu Murata  2 , Takahito Kawano  2 , Makoto Hashizume  2 , Tomohiko Akahoshi  3
Affiliations
Review

Reflectance spectra analysis for mucous assessment

Toru Chiba et al. World J Gastrointest Oncol. .

Abstract

This review report represents an overview of research and development on medical hyperspectral imaging technology and its applications. Spectral imaging technology is attracting attention as a new imaging modality for medical applications, especially in disease diagnosis and image-guided surgery. Considering the recent advances in imaging, this technology provides an opportunity for two-dimensional mapping of oxygen saturation (SatO2) of blood with high accuracy, spatial spectral imaging, and its analysis and provides detection and diagnostic information about the tissue physiology and morphology. Multispectral imaging also provides information about tissue oxygenation, perfusion, and potential function during surgery. Analytical algorithm has been examined, and indication of accurate map of relative hemoglobin concentration and SatO2 can be indicated with preferable resolution and frame rate. This technology is expected to provide promising biomedical information in practical use. Several studies suggested that blood flow and SatO2 are associated with gastrointestinal disorders, particularly malignant tumor conditions. The use and analysis of spectroscopic images are expected to potentially play a role in the detection and diagnosis of these diseases.

Keywords: Diffuse reflectance spectroscopy; Endoscopy; Gastrointestinal cancer; Hemoglobin saturation; Hypoxia; Tumor.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest statement: Authors declare no conflict of interests for this article.

Figures

Figure 1
Figure 1
Spectra components oxyHb and deoxyHb and scatter.
Figure 2
Figure 2
Scheme of hyperspectral camera.
Figure 3
Figure 3
Scheme of liquid crystal tunable filter and digital camera combination.
Figure 4
Figure 4
The system enables to indicate hemoglobin saturation of the mucosa with a practical frame rate for normal examination. An area with relatively high Hb concentration area is enhanced by an Hb concentration mask. The higher Hb concentration and lower Hb saturation areas that are influenced by the tumor are observed as a blue area. A: Experimental cancer model. Red–green–blue video endoscope image of the mouse viscera. The tumor area is outlined by a white line; B: Hb saturation map of the tumor generated by the endoscope system; C: Hb concentration map of the tumor generated by the endoscope system; D: Hb concentration-masked Hb saturation map.
See this image and copyright information in PMC

References

    1. Teng Y, Ding H, Gong Q, Jia Z, Huang L. Monitoring cerebral oxygen saturation during cardiopulmonary bypass using near-infrared spectroscopy: the relationships with body temperature and perfusion rate. J Biomed Opt. 2006;11:024016. - PubMed
    1. Orihashi K, Sueda T, Okada K, Imai K. Near-infrared spectroscopy for monitoring cerebral ischemia during selective cerebral perfusion. Eur J Cardiothorac Surg. 2004;26:907–911. - PubMed
    1. Kumashiro R, Konishi K, Chiba T, Akahoshi T, Nakamura S, Murata M, Tomikawa M, Matsumoto T, Maehara Y, Hashizume M. Integrated Endoscopic System Based on Optical Imaging and Hyperspectral Data Analysis for Colorectal Cancer Detection. Anticancer Res. 2016;36:3925–3932. - PubMed
    1. Utzinger U, Brewer M, Silva E, Gershenson D, Blast RC Jr, Follen M, Richards-Kortum R. Reflectance spectroscopy for in vivo characterization of ovarian tissue. Lasers Surg Med. 2001;28:56–66. - PubMed
    1. Wirkert SJ, Clancy NT, Stoyanov D, Arya S, Hanna GB, Schlemmer HP, Sauer P, Elson DS, Maier-Hein L. Endoscopic Sheffield index for unsupervised in vivo spectral band selection. In: International Workshop on Computer-Assisted and Robotic Endoscopy. Springer, Cham, 2014: 110-120.