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. 2021 Dec 6;16(23):3553-3558.
doi: 10.1002/cmdc.202100504. Epub 2021 Sep 24.

Nanostructured Copper Surface Kills ESKAPE Pathogens and Viruses in Minutes

Guangshun Yi  1 , Siti Nurhanna Riduan  1 , Arunmozhiarasi Armugam  1 , Jin Ting Ong  2   3 , Pei Yun Hon  2   3 , Mohammad Yazid Abdad  2   3 , Shawn Vasoo  2   3 , Brenda Sp Ang  2   3 , Yugen Zhang  1
Affiliations

Nanostructured Copper Surface Kills ESKAPE Pathogens and Viruses in Minutes

Guangshun Yi et al. ChemMedChem. .

Abstract

In the search for a fast contact-killing antimicrobial surface to break the transmission pathway of lethal pathogens, nanostructured copper surfaces were found to exhibit the desired antimicrobial properties. Compared with plain copper, these nanostructured copper surfaces with Cu(OH)2 nano-sword or CuO nano-foam were found to completely eliminate pathogens at a fast rate, including clinically isolated drug resistant species. Additionally these nanostructured copper surfaces demonstrated potential antiviral properties when assessed against bacteriophages, as a viral surrogate, and murine hepatitis virus, a surrogate for SARS-CoV-2. The multiple modes of killing, physical killing and copper ion mediated killing contribute to the superior and fast kinetics of antimicrobial action against common microbes, and ESKAPE pathogens. Prototypes for air and water cleaning with current nanostructured copper surface have also been demonstrated.

Keywords: Cu(OH)2 nanostructure; CuO nanostructure; air disinfection; antimicrobial materials; water disinfection.

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