Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Aug 25;38(4):638-646.
doi: 10.7507/1001-5515.202005050.

[Effects of parameters selection with transcranial direct current stimulation based on real head model]

[Article in Chinese]
Hongli Wang  1   2 , Hongli Yu  1   2 , Chao Wang  1   2 , Guizhi Xu  1   2 , Lei Guo  1   2
Affiliations

[Effects of parameters selection with transcranial direct current stimulation based on real head model]

[Article in Chinese]
Hongli Wang et al. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. .

Abstract
in English, Chinese

Transcranial direct current stimulation (tDCS) is a brain stimulation intervention technique, which has the problem of different criteria for the selection of stimulation parameters. In this study, a four-layer real head model was constructed. Based on this model, the changes of the electric field distribution in the brain with the current intensity, electrode shape, electrode area and electrode spacing were analyzed by using finite element simulation technology, and then the optimal scheme of electrical stimulation parameters was discussed. The results showed that the effective stimulation region decreased and the focusing ability increased with the increase of current intensity. The normal current density of the quadrilateral electrode was obviously larger than that of the circular electrode, which indicated that the quadrilateral electrode was more conducive to current stimulation of neurons. Moreover, the effective stimulation region of the quadrilateral electrode was more concentrated and the focusing ability was stronger. The focusing ability decreased with the increase of electrode area. Specifically, the focusing tended to increase first and then decrease with the increase of electrode spacing and the optimal electrode spacing was 64.0-67.2 mm. These results could provide some basis for the selection of electrical stimulation parameters.

经颅直流电刺激（tDCS）是一种脑刺激干预技术，目前刺激参数的选取缺乏统一标准。本文构建了四层真实头模型，应用有限元仿真技术分析了大脑电场分布随电流强度、电极形状和面积以及电极间距等的变化，探讨了电刺激参数的优选方案。结果显示，随着电流强度增加，有效刺激区域呈减少趋势，聚焦性增强；四边形电极作用后的法向电流密度明显大于圆形电极的数值，这意味着四边形电极更有利于对神经元的刺激，同时有效刺激区域集中，聚焦性更强；随着电极面积增大，聚焦性减弱；随着电极间距的增大，聚焦性呈先增强后减弱的趋势，最佳电极间距为 64.0～67.2 mm。本研究结果可为电刺激参数的选取提供一定的依据。.

Keywords: current intensity; electrode shape and area; electrode spacing; transcranial direct current stimulation.

PubMed Disclaimer

Conflict of interest statement

利益冲突声明：本文全体作者均声明不存在利益冲突。

Figures

图 1
图 1
Steps of model construction 模型构建过程图
图 2
图 2
The maximum and average parameters on the surface of brain under different currents intensities 不同输入电流下大脑表面参数最大值和平均值
图 3
图 3
Effective stimulated regions of brain by different current intensities (the value above the figure is the effective current density) 不同输入电流下大脑有效刺激区域（图上数值为有效电流密度）
图 4
图 4
The split ratio of brain under different current intensities 不同输入电流下大脑组织分流效应
图 5
图 5
The maximum parameters on the surface of brain with different shapes and areas of electrodes 不同形状和面积电极刺激下大脑表面参数最大值
图 6
图 6
The average parameters on the surface of brain with different shapes and areas of electrodes 不同形状和面积电极刺激下大脑表面参数平均值
图 7
图 7
Effective stimulated regions of brain with different shapes and areas of electrodes (the value above the figure is the effective current density) 不同形状和面积电极刺激下大脑有效刺激区域（图形上方数值为有效电流密度）
图 8
图 8
The split ratio of brain with different shapes and areas of electrodes 不同形状和面积电极刺激下大脑组织分流效应
图 9
图 9
The maximum and average parameters on the surface of brain under different electrodes spacing 不同电极间距下大脑表面参数最大值和平均值
图 10
图 10
The brain electric field under different electrodes spacing 不同电极间距下大脑电场分布
图 11
图 11
The split ratio of brain under different electrodes spacing 不同电极间距下大脑组织分流效应
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Nitsche M A, Paulus W Sustained excitability elevations induced by transcranial dc motor cortex stimulation in humans. Neurology. 2001;57(10):1899–1901. doi: 10.1212/WNL.57.10.1899. - DOI - PubMed
    1. Soekadar S R, Witkowski M, Cossio E G, et al Learned EEG-based brain self-regulation of motor-related oscillations during application of transcranial electric brain stimulation: feasibility and limitations. Front Behav Neurosci. 2014;8:93. - PMC - PubMed
    1. Marquez J, Conley A, Karayanidis F, et al Anodal direct current stimulation in the healthy aged: effects determined by the hemisphere stimulated. Restor Neurol Neurosci. 2015;33(4):509–519. - PMC - PubMed

    1. Hummel F C, Cohen L G. Non-invasive brain stimulation: a new strategy to improve neurorehabilitation after stroke?. Lancet Neurol, 2006, 5(8): 708-712.

    1. Nitsche M A, Cohen L G, Wassermann E M, et al Transcranial direct current stimulation: state of the art 2008. Brain Stimul. 2008;1(3):206–223. doi: 10.1016/j.brs.2008.06.004. - DOI - PubMed

LinkOut - more resources