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Case Reports
. 2021 Dec;197(12):1143-1147.
doi: 10.1007/s00066-021-01814-0. Epub 2021 Aug 30.

Successful salvage of recurrent leptomeningeal disease in large cell neuroendocrine lung cancer with stereotactic radiotherapy

Seok-Yun Lee  1 , Nicoletta Lomax  2 , Sven Berkmann  3 , Kathrin Vollmer  4 , Oliver Riesterer  2 , Stephan Bodis  2 , Susanne Rogers  2
Affiliations
Case Reports

Successful salvage of recurrent leptomeningeal disease in large cell neuroendocrine lung cancer with stereotactic radiotherapy

Seok-Yun Lee et al. Strahlenther Onkol. 2021 Dec.

Abstract

A 70-year old male with stage I large cell neuroendocrine carcinoma (LCNEC) of the lung underwent resection of a metachronous 5 cm brain metastasis and received postoperative hypofractionated stereotactic radiotherapy (hfSRT). Five sequential nodular leptomeningeal metastases up to 5.3 cm in diameter were diagnosed on MRI within 10 months and were treated with SRT. Currently the patient has no evidence of intracranial disease 24 months after last irradiation without chemotherapy or whole brain radiotherapy. This is the first report of sustained complete remission of multiple large leptomeningeal metastases achieved with hfSRT, highlighting this brain-sparing approach in selected patients with LCNEC lung cancer.

Keywords: Hypo-fractionated radiosurgery; Large cell neuroendocrine carcinoma; Leptomeningeal disease; Radiosurgery.

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