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Editorial
. 2021 Aug 31;144(9):680-683.
doi: 10.1161/CIRCULATIONAHA.121.056140. Epub 2021 Aug 30.

Challenging Statin Pleiotropy: Preeclampsia

Janet Wei  1 , James K Liao  2 , C Noel Bairey Merz  1
Affiliations
Editorial

Challenging Statin Pleiotropy: Preeclampsia

Janet Wei et al. Circulation. .
No abstract available

Keywords: Editorials; cardiovascular diseases; hydroxymethylglutaryl-CoA reductase inhibitors; inflammation; lipoproteins, LDL; pre-eclampsia.

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Figures

Figure :
Figure :. Pleiotropic effects of statins.
Plus sign = enhanced/activated; minus sign = inhibited; AT11 = angiotensin 1; ET-1 = endothelin 1; hs-CRP = high-sensitivity C-reactive protein; MMPs = matrix metalloproteinases; NO = nitric oxide; PAI-1 = plasminogen activator inhibitor-1; ROS = reactive oxygen species; SMC = smooth muscle cell; TF = tissue factor; t-PA = tissue-type plasminogen activator; TXA2 = thromboxane A2. (Reprinted with permission)
See this image and copyright information in PMC

Comment on

  • Pravastatin Versus Placebo in Pregnancies at High Risk of Term Preeclampsia.
    Döbert M, Varouxaki AN, Mu AC, Syngelaki A, Ciobanu A, Akolekar R, De Paco Matallana C, Cicero S, Greco E, Singh M, Janga D, Del Mar Gil M, Jani JC, Bartha JL, Maclagan K, Wright D, Nicolaides KH. Döbert M, et al. Circulation. 2021 Aug 31;144(9):670-679. doi: 10.1161/CIRCULATIONAHA.121.053963. Epub 2021 Jun 24. Circulation. 2021. PMID: 34162218 Clinical Trial.

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