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. 2022 Jan;111(1):76-85.
doi: 10.1111/apa.16088. Epub 2021 Sep 5.

Local protocol helped to deliver vitamin D levels more accurately in preterm infants

Mauras Mathilde  1 , Marine Butin  2   3   4 , Roy Pascal  4   5   6 , Franck Plaisant  2   3   4 , Sophie Laborie  2   3 , Justine Bacchetta  1   4   7   8
Affiliations

Local protocol helped to deliver vitamin D levels more accurately in preterm infants

Mauras Mathilde et al. Acta Paediatr. 2022 Jan.

Abstract

Aim: This study retrospectively evaluated the effectiveness and safety of a local hospital protocol of vitamin D supplementation for preterm infants, which was modified in 2016.

Methods: We focussed on 99 preterm infants born before 31 weeks of gestation and admitted to the neonatal intensive care unit at the Femme Mere Enfant Hospital, Bron, France, from 1 January to 31 December 2018. Calcium and urinary calcium were measured, and 25-hydroxy vitamin D (25(OH)D) levels were monitored monthly and supplementation was adjusted, with 50-120 nmol/L considered normal. The results are presented as medians and interquartile ranges.

Results: The infants were enrolled at a gestational age of 28.0 [26.9-29.1] weeks and birth weight of 960 [800-1160] g. When they were discharged at 37.3 [35.2-39.8] weeks, the overall 25(OH)D level was 98 [79-140] nmol/L: 4% had low levels, 63% had normal levels and 33% had high levels. Vitamin D supplementation was withdrawn for 60% more than one month before discharge. Rickets or fractures were not reported.

Conclusion: The modified protocol limited underdosing and significant overdosing, but moderate hypervitaminosis D was still frequent. Urgent studies are needed to determine the optimal supplementation and clinical impact of 25(OH)D on comorbidities in preterm infants.

Keywords: 25-hydroxyvitamin D; hypervitaminosis D; nephrocalcinosis; preterm infants; vitamin D deficiency.

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References

REFERENCES

    1. Abrams SA. Calcium and Vitamin D Requirements of Enterally Fed Preterm Infants. Pediatrics. 2013;131(5):e1676-1683.
    1. Agostoni C, Buonocore G, Carnielli VP, et al. Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2010;50(1):85-91.
    1. Anderson-Berry A, Thoene M, Wagner J, et al. Randomized trial of two doses of vitamin D3 in preterm infants <32 weeks: dose impact on achieving desired serum 25(OH)D3 in a NICU population. PLoS ONE. 2017;12(10):e0185950.
    1. Bozkurt O, Uras N, Sari FN, et al. Multi-dose vitamin d supplementation in stable very preterm infants: prospective randomized trial response to three different vitamin D supplementation doses. Early Hum Dev. 2017;112:54-59.
    1. Kołodziejczyk A, Borszewska-Kornacka MK. monitored supplementation of vitamin d in preterm neonates-a primary report. Dev Period Med. 2015;19(3 Pt 1):313-318.

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