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Review
. 2021 Aug 31;25(1):310.
doi: 10.1186/s13054-021-03670-x.

Measuring vitamin C in critically ill patients: clinical importance and practical difficulties-Is it time for a surrogate marker?

Sander Rozemeijer  1 , Frans A L van der Horst  2 , Angélique M E de Man  3
Affiliations
Review

Measuring vitamin C in critically ill patients: clinical importance and practical difficulties-Is it time for a surrogate marker?

Sander Rozemeijer et al. Crit Care. .

Erratum in

Abstract

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2021. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2021 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from https://link.springer.com/bookseries/8901 .

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Degradation of vitamin C (ascorbic acid). By donating two electrons, dehydroascorbic acid (DHA) is formed. After hydrolysis, DHA is irreversibly degraded to 2,3-diketogulonic acid, leading to further breakdown products of vitamin C. The half-life of DHA is only minutes due to hydrolytic ring rupture. DHA can be reversibly reduced (recycling) by glutathione or enzyme-dependent mechanisms
Fig. 2
Fig. 2
Image of the portable RedoxSYS analyzer and disposable strip. From [36] with permission
Fig. 3
Fig. 3
Scatter plot showing the association between the static oxidation-reduction potential (sORP) and plasma vitamin C concentration. From [17] with permission
See this image and copyright information in PMC

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