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. 2021 Dec:13:100318.
doi: 10.1016/j.onehlt.2021.100318. Epub 2021 Aug 26.

Evidence of neutralizing antibodies against SARS-CoV-2 in domestic cats living with owners with a history of COVID-19 in Lima - Peru

Luis M Jara  1 , Cusi Ferradas  2 , Francesca Schiaffino  1 , Camila Sánchez-Carrión  3 , Ana Martínez-Vela  4 , Alexandra Ulloa  3 , Gisela Isasi-Rivas  5 , Angela Montalván  5 , Luis Guevara Sarmiento  5 , Manolo Fernández  5 , Mirko Zimic  5   6
Affiliations

Evidence of neutralizing antibodies against SARS-CoV-2 in domestic cats living with owners with a history of COVID-19 in Lima - Peru

Luis M Jara et al. One Health. 2021 Dec.

Abstract

SARS-CoV-2 can infect a variety of wild and domestic animals worldwide. Of these, domestic cats are highly susceptible species and potential viral reservoirs. As such, it is important to investigate disease exposure in domestic cats in areas with active community transmission and high disease prevalence. In this report we demonstrate the presence of serum neutralizing antibodies against the receptor binding-domain (RBD) of the SARS-CoV-2 in cats whose owners had been infected with SARS-CoV-2 in Lima, Peru, using a commercial competitive ELISA SARS-CoV-2 Surrogate Virus Neutralization Test. Out of 41 samples, 17.1% (7/41) and 31.7% (13/41) were positive, using the cut-off inhibition value of 30% and 20%, respectively. Not all cats living in a single house had detectable neutralizing antibodies showing heterogenous exposure and immunity among cohabiting animals. This is the first report of SARS-COV-2 exposure of domestic cats in Lima, Peru. Further studies are required to ascertain the prevalence of SARS-COV-2 exposure among domestic cats.

Keywords: COVID-19; Cats; Neutralizing antibodies; One health; SARS-CoV-2; Serology.

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Figures

Fig. 1
Fig. 1
Percent inhibition against SARS-COV-2 receptor binding-domain (RBD) in serum of domestic cats whose owners had a history of COVID-19 (n = 41). C: controls, (−): negative, (+): positive. The 17.1% (7/41) and 31.7% (13/41) shows the frequency of cats with neutralizing antibodies with 30% and 20% of cut-off values of inhibition, respectively.
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