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. 2022 Jun;200(6):2848-2856.
doi: 10.1007/s12011-021-02891-z. Epub 2021 Aug 30.

Selenium Attenuates Doxorubicin-Induced Cardiotoxicity Through Nrf2-NLRP3 Pathway

Hai-Bing Yang  1 , Zhao-Yang Lu  2 , Wei Yuan  3 , Wei-Dong Li  3 , Shang Mao  4
Affiliations

Selenium Attenuates Doxorubicin-Induced Cardiotoxicity Through Nrf2-NLRP3 Pathway

Hai-Bing Yang et al. Biol Trace Elem Res. 2022 Jun.

Abstract

Selenium (Se), an essential nutrient for humans, has been reported to possess cardioprotective effect. However, the protective effects of Se against doxorubicin (DOX)-induced cardiotoxicity and the underlying mechanism are rarely reported. In this study, we sought to explore whether Se protected against DOX-induced cardiotoxicity by inhibiting Nrf2-NLRP3 pathway. We found that Se treatment effectively alleviated DOX-induced myocardial dysfunctions, decreasing plasma markers associated with myocardial injury. Moreover, Se treatment significantly inhibited DOX-induced oxidative damages and pro-inflammatory cytokine expression in heart tissues. Furthermore, Se treatment markedly promoted the expression of Nrf2 and prevented the activation of NLRP3 inflammasome. Importantly, suppression of Nrf2 abolished the cardioprotective effects of Se and diminished the inhibition of Se on NLRP3 inflammasome. Collectively, our study demonstrated that Se might protect against DOX-induced cardiotoxicity via regulating Nrf2-NLRP3 pathway. Se supplementation may be a potential therapeutic strategy to protect against DOX-induced cardiac injury.

Keywords: Doxorubicin; Heart; NLRP3; Nrf2; Selenium.

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References

    1. Ferreira AL, Matsubara LS, Matsubara BB (2008) Anthracycline-induced cardiotoxicity. Cardiovasc Hematol Agents Med Chem 6(4):278–281. https://doi.org/10.2174/187152508785909474 - DOI - PubMed
    1. Plummer C, Driessen C, Szabo Z, Mateos MV (2019) Management of cardiovascular risk in patients with multiple myeloma. Blood Cancer J 9(3):26. https://doi.org/10.1038/s41408-019-0183-y - DOI - PubMed - PMC
    1. Yeh ET, Bickford CL (2009) Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management. J Am Coll Cardiol 53(24):2231–2247. https://doi.org/10.1016/j.jacc.2009.02.050 - DOI - PubMed
    1. Boussada M, Ali RB, Said AB, Bokri K, Akacha AB, Dziri C, El May MV (2017) Selenium and a newly synthesized thiocyanoacetamide reduce doxorubicin gonadotoxicity in male rat. Biomed Pharmacother 89:1005–1017. https://doi.org/10.1016/j.biopha.2017.03.002 - DOI - PubMed
    1. Cengiz O, Baran M, Balcioglu E, Suna PA, Bilgici P, Goktepe O, Onder GO, Goc R, Yay A (2021) Use of selenium to ameliorate doxorubicin induced hepatotoxicity by targeting pro-inflammatory cytokines. Biotech Histochem 96(1):67–75. https://doi.org/10.1080/10520295.2020.1760353 - DOI - PubMed

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