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Comment
. 2022 Feb;74(2):369-371.
doi: 10.1002/art.41957. Epub 2021 Dec 27.

VEXAS syndrome with systemic lupus erythematosus: expanding the spectrum of associated conditions

Aman Sharma  1 , Gsrsnk Naidu  1 , Prateek Deo  1 , David B Beck  2
Affiliations
Comment

VEXAS syndrome with systemic lupus erythematosus: expanding the spectrum of associated conditions

Aman Sharma et al. Arthritis Rheumatol. 2022 Feb.
No abstract available

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Conflict of interest statement

Conflict of Interest: None

Figures

Figure 1
Figure 1
showing the clinical course and response to therapy. MCV- Mean corpuscular volume, Hb- haemoglobin, TLC- total leucocyte count, ANA- anti nuclear antibodies, DVT- deep venous thrombosis, SLE- systemic lupus erythematosus, MMF-Mycophenolate mofetil, HCQ- hydroxychloroquine, IVIG-intravenous immunoglobulin, UTI- urinary tract infection, VEXAS- Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome syndrome
See this image and copyright information in PMC

Comment on

  • Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.
    Beck DB, Ferrada MA, Sikora KA, Ombrello AK, Collins JC, Pei W, Balanda N, Ross DL, Ospina Cardona D, Wu Z, Patel B, Manthiram K, Groarke EM, Gutierrez-Rodrigues F, Hoffmann P, Rosenzweig S, Nakabo S, Dillon LW, Hourigan CS, Tsai WL, Gupta S, Carmona-Rivera C, Asmar AJ, Xu L, Oda H, Goodspeed W, Barron KS, Nehrebecky M, Jones A, Laird RS, Deuitch N, Rowczenio D, Rominger E, Wells KV, Lee CR, Wang W, Trick M, Mullikin J, Wigerblad G, Brooks S, Dell'Orso S, Deng Z, Chae JJ, Dulau-Florea A, Malicdan MCV, Novacic D, Colbert RA, Kaplan MJ, Gadina M, Savic S, Lachmann HJ, Abu-Asab M, Solomon BD, Retterer K, Gahl WA, Burgess SM, Aksentijevich I, Young NS, Calvo KR, Werner A, Kastner DL, Grayson PC. Beck DB, et al. N Engl J Med. 2020 Dec 31;383(27):2628-2638. doi: 10.1056/NEJMoa2026834. Epub 2020 Oct 27. N Engl J Med. 2020. PMID: 33108101 Free PMC article.

References

    1. Beck DB, Ferrada MA, Sikora KA, Ombrello AK, Collins JC, Pei W, et al. Somatic mutations in UBA1 and severe adut-onset autoinflammatory disease. N Engl J Med 2020; 383: 2628–38. - PMC - PubMed

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