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Review
. 2021 Oct;87(1):181-203.
doi: 10.1111/prd.12385.

Periodontitis and rheumatoid arthritis: What have we learned about their connection and their treatment?

Jerián González-Febles  1   2 , Mariano Sanz  1   2
Affiliations
Review

Periodontitis and rheumatoid arthritis: What have we learned about their connection and their treatment?

Jerián González-Febles et al. Periodontol 2000. 2021 Oct.

Abstract

Rheumatoid arthritis and periodontitis are chronic inflammatory diseases defined respectively by the destruction of the articular cartilage and tooth-supporting periodontal tissues. Although the epidemiologic evidence for an association between these two diseases is still scarce, there is emerging scientific information linking specific bacterial periodontal pathogens, such as Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, in the citrullination process, leading to autoantibody formation and compromised immunotolerance of the susceptible patient to rheumatoid arthritis. In this review, we update the existing information on the evidence, not only regarding the epidemiologic association, but also the biologic mechanisms linking these two diseases. Finally, we review information emerging from intervention studies evaluating whether periodontal treatment could influence the initiation and progression of rheumatoid arthritis.

Keywords: Porphyromonas gingivalis; anti-citrullinated protein antibodies; citrullination; periodontitis; rheumatoid arthritis; rheumatoid factor.

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References

REFERENCES

    1. Turesson C, O'Fallon WM, Crowson CS, Gabriel SE, Matteson EL. Extra-articular disease manifestations in rheumatoid arthritis: incidence trends and risk factors over 46 years. Ann Rheum Dis. BMJ Publishing Group Ltd. 2003;62(8):722-727.
    1. Aviña-Zubieta JA, Choi HK, Sadatsafavi M, Etminan M, Esdaile JM, Lacaille D. Risk of cardiovascular mortality in patients with rheumatoid arthritis: A meta-analysis of observational studies. Arthritis Rheum. 2008;59(12):1690-1697.
    1. de Molon RS, Rossa C Jr, Thurlings RM, Cirelli JA, Koenders MI. Linkage of periodontitis and rheumatoid arthritis: current evidence and potential biological interactions. IJMS. 2019;20(18):4541-4635.
    1. Symmons DP, Barrett EM, Bankhead CR, Scott DG, Silman AJ. The incidence of rheumatoid arthritis in the United Kingdom: results from the Norfolk Arthritis Register. Br J Rheumatol. 1994;33(8):735-739.
    1. Seoane-Mato D, Sánchez-Piedra C, Díaz-González F, Bustabad S. Prevalence of rheumatic diseases in adult population in Spain. Episer 2016 study. Ann Rheum Dis. 2018;77(Suppl 2):535.

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