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Comment
. 2021 Aug 31;6(1):324.
doi: 10.1038/s41392-021-00743-9.

Boosting the cellular potency of embryonic stem cells by spliceosome targeting

Wilfried A Kues  1
Affiliations
Comment

Boosting the cellular potency of embryonic stem cells by spliceosome targeting

Wilfried A Kues. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The author declares no competing interests.

Figures

Fig. 1
Fig. 1
Potential applications of totipotent ES cells. Spliceosome targeting by RNA interference or the specific inhibitor pladienolide B seems to convert pluri- to totipotent ES cells, which were shown to have a bi-directional developmental capacity to embryonic and extra-embryonic cell lineages: allowing to explore in vitro differentiation of extra-embryonal tissue and organoids, translation to the maintenance of pluripotent cells of other mammal species, a better molecular understanding of cellular potency in stem cells and cancer, and potentially to develop more specific therapeutic treatments
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References

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