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. 2021 Jun 2:39:97.
doi: 10.11604/pamj.2021.39.97.26796. eCollection 2021.

The role of bacteriological monitoring using culture and drug susceptibility tests (CDST) on treatment outcomes among MDR/RR-TB patients on treatment: a cohort analysis of patients enrolled on treatment 2010-2015 in Zimbabwe

Ronnie Matambo  1 , Shungu Mutero-Munyati  1 , Vongai Mildred Pepuka  1 , Tendai Nkomo  2 , Charles Sandy  2 , Mkhokheli Ngwenya  3 , Gilchriste Ndongwe  4 , Elliot Chikaka  5 , Sungano Mharakurwa  5 , George Nyandoro  6
Affiliations

The role of bacteriological monitoring using culture and drug susceptibility tests (CDST) on treatment outcomes among MDR/RR-TB patients on treatment: a cohort analysis of patients enrolled on treatment 2010-2015 in Zimbabwe

Ronnie Matambo et al. Pan Afr Med J. .

Abstract

Introduction: an estimated 25% of the world population is infected with Mycobacterium tuberculosis. In 2017, new tuberculosis cases were estimated at 10 million, while 1.6 million tuberculosis related deaths were recorded, 25% residing in Africa. Treatment outcomes of multi drug resistant Tuberculosis patients in Zimbabwe has been well documented but the role of bacteriological monitoring on treatment outcomes has not been systematically evaluated. The objective of the study was to determine the role of bacteriological monitoring using culture and drug susceptibility tests on treatment outcomes among patients with multi drug resistant tuberculosis.

Methods: a retrospective, secondary data analysis was conducted using routinely collected data of patients with multi drug resistant TB in Zimbabwe. Frequencies were used to summarize categorical variables and a generalized linear model with a log-link function and a Poisson distribution was used to assess factors associated with unfavourable outcomes. The level of significance was set at P-Value<0.05.

Results: about the study collected data from 473 records of patients with an average age of 36.35 years. Forty-nine percent (49%) were male and 51% were female. Results showed that when a patient has baseline culture result missing, has no culture conversion result, regardless of having a follow up culture and drug susceptibility test result, the risk of developing unfavourable outcomes increase by 3.9 times compared to a patient who has received all the three (3) bacteriological monitoring tests.

Conclusion: results highlights the need for consistent bacteriological monitoring of patients to avert unfavourable treatment outcomes.

Keywords: Multi-drug resistant tuberculosis; bacteriological monitoring; drug resistant tuberculosis; drug susceptibility tests; tuberculosis treatment outcomes.

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Conflict of interest statement

The authors declare no competing interests.

References

    1. World Health Organization . Geneva, Switzerland: World Health Organisation (WHO); 2018. Global tuberculosis report 2018.
    1. Kurbatova E, Taylor A, Gammino V, Danilovitz M, Falzon D, Gelmanova I, et al. Predictors of poor outcomes among patients treated for multidrug-resistant tuberculosis at DOTS-plus projects. Tuberculosis. 2012 Sep;92(5):397–403. - PMC - PubMed
    1. Parmar MM, Sachdeva KS, Dewan PK, Rade K, Nair SA, Pant R, et al. Unacceptable treatment outcomes and associated factors among India´s initial cohorts of multidrug-resistant tuberculosis (MDR-TB) patients under the revised national TB control programme (2007-2011): evidence leading to policy enhancement. PLoS One. 2018 Apr 11;13(4):e0193903. - PMC - PubMed
    1. World Health Organisation . Geneva, Switzerland: World Health Organisation (WHO); 2019. WHO consolidated guidelines on drug-resistant tuberculosis treatment.
    1. Kliiman K, Altraja A. Predictors of poor treatment outcome in multi-and extensively drug-resistant pulmonary TB. Eur Respir J. 2009 May;33(5):1085–94. - PubMed

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