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. 2019 Jun 16:8:e1157.
doi: 10.31661/gmj.v8i0.1157. eCollection 2019.

Effects of Acute and Subchronic Anodal Transcranial Direct Current Stimulation (tDCS) on Morphine-Induced Responses in Hotplate Apparatus

Seyyed Saeid Anvari  1 , Mohammad Nasehi  2 , Mohammad-Reza Zarrindast  1   3
Affiliations

Effects of Acute and Subchronic Anodal Transcranial Direct Current Stimulation (tDCS) on Morphine-Induced Responses in Hotplate Apparatus

Seyyed Saeid Anvari et al. Galen Med J. .

Abstract

Background: The endogenous opioid system plays a basic role in pain suppression. The opiate analgesia is the most powerful and useful technique for reducing severe pain in many medical conditions. Transcranial direct current stimulation (tDCS) is a neuromodulator technique by which the cerebral cortex is stimulated with a weak and constant electrical current by the painless and non-invasive method.

Materials and methods: In this experimental study, we investigated the effect of tDCS on morphine (1.25, 2.5 and 5 mg/kg)-induced pain responses; as we applied left prefrontal anodal stimulation with 0.2 mA intensity and 20 minutes.

Results: our results revealed that the acute (One-time electrical stimulation 24 hours after the last administration of morphine three days) and subchronic (three times electrical stimulation; one session/day before each administration of morphine three days) left prefrontal anodal tDCS does not alter pain perception induced by different dose of morphine significantly.

Conclusion: Finally, our data indicated that there is no potentiated effect between acute tDCS or subchronic tDCS and morphine administration with tested parameters significantly.

Keywords: Anodal; Morphine; Pain; Prefrontal Cortex; tDCS.

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