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. 2021 Sep 1;224(5):754-763.
doi: 10.1093/infdis/jiab124.

Longitudinal Assessment of Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Immune Responses for Six Months Based on the Clinical Severity of Coronavirus Disease 2019

Ji Yun Noh  1 , Jeong-Eun Kwak  2 , Jeong-Sun Yang  3 , Soon Young Hwang  4 , Jin Gu Yoon  1 , Hye Seong  1 , Hakjun Hyun  1 , Chae Seung Lim  5 , Soo-Young Yoon  5 , Jungsang Ryou  3 , Joo-Yeon Lee  3 , Sung-Soon Kim  3 , Su-Hyung Park  2   6 , Hee Jin Cheong  1 , Woo Joo Kim  1 , Eui-Cheol Shin  2   6 , Joon Young Song  1
Affiliations

Longitudinal Assessment of Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Immune Responses for Six Months Based on the Clinical Severity of Coronavirus Disease 2019

Ji Yun Noh et al. J Infect Dis. .

Erratum in

Abstract

Background: There is insufficient data on the longevity of immunity acquired after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Methods: We aimed to evaluate the duration of SARS-CoV-2-specific humoral and cellular immunity according to the clinical severity of coronavirus disease 2019 (COVID-19). The study population comprised asymptomatic (n = 14), symptomatic/nonpneumonic (n = 42), and pneumonic (n = 41) patients.

Results: The anti-SARS-CoV-2 immunoglobulin class G and neutralizing antibody (NAb) titers lasted until 6 months after diagnosis, with positivity rates of 66.7% and 86.9%, respectively. Older age, prolonged viral shedding, and accompanying pneumonia were more frequently found in patients with sustained humoral immunity. Severe acute respiratory syndrome coronavirus 2-specific T-cell response was strongly observed in pneumonic patients and prominent in individuals with sustained humoral immunity.

Conclusions: In conclusion, most (>85%) patients carry NAb until 6 months after diagnosis of SARS-CoV-2 infection, providing insights for establishing vaccination strategies against COVID-19.

Keywords: COVID-19; SARS-CoV-2; cellular immunity; humoral immunity; longevity.

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