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Randomized Controlled Trial
. 2022 Jan;23(1):39-47.
doi: 10.1111/hiv.13158. Epub 2021 Sep 1.

Structured medicines reviews in HIV outpatients: a feasibility study (The MOR Study)

Heather A Leake Date  1 , Katie Alford  1   2 , Natalia Hounsome  2 , David Moore  3 , Kin Ing  3 , Jaime H Vera  1   2
Affiliations
Free article
Randomized Controlled Trial

Structured medicines reviews in HIV outpatients: a feasibility study (The MOR Study)

Heather A Leake Date et al. HIV Med. 2022 Jan.
Free article

Abstract

Objectives: Polypharmacy in people living with HIV (PLWH) increases the risks of medicine-related problems (events or circumstances involving drug therapy that actually or potentially interfere with desired health outcomes). We aimed to examine the feasibility and acceptability of a Medicines Management Optimisation Review (MOR) toolkit in HIV outpatients.

Methods: This was a multi-centre randomized controlled study across four HIV centres. In all, 200 PLWH on combination antiretroviral therapy, either > 50 years old or < 50 years with other comorbidities, were enrolled to have a MOR or received standard pharmaceutical care. The primary outcome was the difference in the number of medicine-related problems (MRPs) between intervention and standard care groups at baseline and 6 months. Acceptability, cost of the intervention and health-related quality of life were also examined.

Results: In all, 164 patients were analysed: 70 in the intervention group and 94 in the standard care group. A significant number of MRPs were detected in those patients receiving MOR compared with the standard care group at baseline (93 vs. 2; p = 0.001, z = -8.6, r = 0.6) and 6 months (33 vs. 3; p = 0.001, z = -5.7, r = 0.4). A significant reduction in the number of new MRPs at 6 months in the intervention group versus baseline was also observed (p = 0.001, Z = -3.7, r = 0.2); 44% of MRPs were fully resolved at baseline and 51% at 6 months. No changes in health-related quality of life following MOR or between MOR and standard care groups were observed. The MORs were highly acceptable among patients and healthcare professionals.

Conclusions: The MOR toolkit was feasible and acceptable, suggesting that HIV outpatient services might consider implementing MOR for targeted populations under their care.

Keywords: combination antiretroviral therapy; drug interactions; medication-related problems; polypharmacy; structured medicines reviews.

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References

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