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Case Reports
. 2022 Mar 1;61(5):719-722.
doi: 10.2169/internalmedicine.6696-20. Epub 2021 Aug 31.

Successful Resection of a Primary Dedifferentiated Tracheal Liposarcoma Causing Tracheal Stenosis

Akane Ishida  1 , Nobuhiro Hanai  2 , Masahide Oki  1 , Akari Iwakoshi  3
Affiliations
Case Reports

Successful Resection of a Primary Dedifferentiated Tracheal Liposarcoma Causing Tracheal Stenosis

Akane Ishida et al. Intern Med. .

Abstract

A 68-year-old woman was admitted with a persistent cough and dyspnea that had persisted for 4 months prior. Chest computed tomography revealed a tumor protruding from the membranous portion of the trachea. She underwent tumor resection via rigid and flexible bronchoscopy to relieve the symptoms and obtain a diagnosis. After the procedure, she was diagnosed with tracheal liposarcoma. Three months after the procedure, she underwent complete surgical tumor resection. Liposarcoma is a mesenchymal tumor that usually develops in the extremities and the retroperitoneum. Tracheal liposarcoma is extremely rare. To the best of our knowledge, this is only the second reported case.

Keywords: liposarcoma; tracheal liposarcoma; tracheal tumor.

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Conflict of interest statement

The authors state that they have no Conflict of Interest (COI).

Figures

Figure 1.
Figure 1.
Chest CT reveals a tracheal tumor protruding from the membranous portion.
Figure 2.
Figure 2.
Bronchoscopic view of the tumor obstructing the trachea.
Figure 3.
Figure 3.
A, B: Hematoxylin and Eosin staining revealed spindle cell tumor proliferation and atypical mitotic activity with intracellular edema and inflammatory cell infiltration (A ×40), (B ×400). C: Immunohistochemical images of αSMA. D: Immunohistochemical images of vimentin. E: The FISH analysis using probes for MDM2 (red signals) and centromere 12 (green signals) revealed high-level MDM2 amplification. The amplified signals formed a large cluster.
Figure 4.
Figure 4.
A, B: The histopathological examination of specimens obtained via total laryngectomy (A ×1.25) (B ×20; the square portion of A). (a) The tracheal lumen, (b) the tumor, (c) tracheal cartilage, (d) the esophageal muscularis propria, (e) the esophageal mucosal epithelium.
See this image and copyright information in PMC

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