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. 2022 Jan 1;41(1):45-47.
doi: 10.1097/INF.0000000000003311.

Rapid Detection of Carbapenemase-producing Enterobacteriaceae From Blood Culture Bottles of Known CPE Carriers: Real-world Experience

Or Kriger  1   2 , Rachel Shatzman-Steuerman  2 , Gillian Smollan  2 , Natasha Belausov  2 , Gayane Sarkisian  2 , Sharon Amit  2
Affiliations

Rapid Detection of Carbapenemase-producing Enterobacteriaceae From Blood Culture Bottles of Known CPE Carriers: Real-world Experience

Or Kriger et al. Pediatr Infect Dis J. .

Abstract

We used a rapid antigen test for the detection of carbapenemases directly from positive blood culture bottles of pediatric hemato-oncologic patients, known carriers of carbapenemase-producing enterobacteriaceae. Resistance mechanism was detected within 15 minutes of observing Gram-negative bacilli from a positive bottle, leading to treatment modification. This simple-to-use, inexpensive assay shortens the interval between empiric to tailored antimicrobial therapy.

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Conflict of interest statement

The study was funded by the research group with no external support. The authors have no conflicts of interest to disclose.

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