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. 2021 Nov;47(11):1334-1336.
doi: 10.1007/s00134-021-06512-0. Epub 2021 Sep 1.

Cytokine adsorption in severe, refractory septic shock

Pedro David Wendel Garcia  1 , Matthias Peter Hilty  1 , Ulrike Held  2 , Eva-Maria Kleinert  1 , Marco Maggiorini  3
Affiliations

Cytokine adsorption in severe, refractory septic shock

Pedro David Wendel Garcia et al. Intensive Care Med. 2021 Nov.
No abstract available

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Conflict of interest statement

MM reported receiving research grants from CytoSorbents Europe GmbH (Berlin, Germany) and Baxter International Inc. (Deerfield, USA), as well as personal fees for his work as external consultant from Baxter International Inc. (Deerfield, USA) and Toray Industries Inc. (Tokyo, Japan). All other authors declare no conflicts of interest.

Figures

Fig. 1
Fig. 1
Primary end points. Temporal development of (a) interleukin-6 levels and (b) the vasopressor dependency index. Depicted are notched box plots with median and interquartile range, and whiskers extending from the difference of the first quartile and 1.5 times the interquartile range, to the sum of the third quartile and 1.5 times the interquartile range. Notches represent the 95% confidence interval of the median. The x-axis portrays the time in hours ensuing severe, refractory septic shock onset. (c) Kaplan–Meier curves for 30-day intensive care unit survival stratified by control and cytokine adsorption group, plotted in blue and red colors, respectively. Shaded areas represent the 95% confidence interval. The x-axis portrays the time in days ensuing severe, refractory septic shock onset. The computed hazard ratio assesses the cytokine adsorption group using the control group as reference. The 95% confidence interval is given in parentheses. Hazard ratios were modeled by means of a Fine and Gray competing risk analysis. Censoring reflects patients having left the intensive care unit alive. The underlying table presents the patients at risk per time point with the number of censored patients given in parentheses
See this image and copyright information in PMC

Comment in

References

    1. Honore PM, Hoste E, Molnár Z, Jacobs R, Joannes-Boyau O, Malbrain MLNG, Forni LG. Cytokine removal in human septic shock: where are we and where are we going? Ann Intensive Care. 2019;9:56. doi: 10.1186/s13613-019-0530-y. - DOI - PMC - PubMed
    1. Poli EC, Rimmelé T, Schneider AG. Hemoadsorption with CytoSorb®. Intensive Care Med. 2019;45:236–239. doi: 10.1007/s00134-018-5464-6. - DOI - PubMed
    1. Schädler D, Pausch C, Heise D, Meier-Hellmann A, Brederlau J, Weiler N, Marx G, Putensen C, Spies C, Jörres A, Quintel M, Engel C, Kellum JA, Kuhlmann MK. The effect of a novel extracorporeal cytokine hemoadsorption device on IL-6 elimination in septic patients: a randomized controlled trial. PLoS ONE. 2017;12:e0187015. doi: 10.1371/journal.pone.0187015. - DOI - PMC - PubMed
    1. Supady A, Weber E, Rieder M, Lother A, Niklaus T, Zahn T, Frech F, Müller S, Kuhl M, Benk C, Maier S, Trummer G, Flügler A, Krüger K, Sekandarzad A, Stachon P, Zotzmann V, Bode C, Biever PM, Staudacher D, Wengenmayer T, Graf E, Duerschmied D. Cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation (CYCOV): a single centre, open-label, randomised, controlled trial. Lancet Respir Med. 2021 doi: 10.1016/S2213-2600(21)00177-6. - DOI - PMC - PubMed
    1. Bonavia A, Groff A, Karamchandani K, Singbartl K. Clinical utility of extracorporeal cytokine hemoadsorption therapy: a literature review. Blood Purif. 2018;46:337–349. doi: 10.1159/000492379. - DOI - PubMed