Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Lonneke A van Tuijl¹, Adri C Voogd^{2

3

4}, Alexander de Graeff⁵, Adriaan W Hoogendoorn^{6

7}, Adelita V Ranchor¹, Kuan-Yu Pan⁶, Maartje Basten⁸, Femke Lamers⁶, Mirjam I Geerlings⁸, Jessica G Abell⁹, Philip Awadalla^{10

11

12}, Marije F Bakker⁸, Aartjan T F Beekman⁶, Ottar Bjerkeset^{13

14}, Andy Boyd¹⁵, Yunsong Cui¹⁶, Henrike Galenkamp¹⁷, Bert Garssen¹, Sean Hellingman¹⁸, Martijn Huisman^{19

20}, Anke Huss²¹, Melanie R Keats²², Almar A L Kok^{6

19}, Annemarie I Luik^{23

24}, Nolwenn Noisel²⁵, N Charlotte Onland-Moret⁸, Yves Payette²⁵, Brenda W J H Penninx⁶, Lützen Portengen²¹, Ina Rissanen⁸, Annelieke M Roest²⁶, Judith G M Rosmalen²⁷, Rikje Ruiter^{23

28}, Robert A Schoevers²⁹, David M Soave^{10

18}, Mandy Spaan³⁰, Andrew Steptoe⁹, Karien Stronks¹⁷, Erik R Sund^{13

31

32}, Ellen Sweeney¹⁶, Alison Teyhan¹⁵, Ilonca Vaartjes⁸, Kimberly D van der Willik^{23

30}, Flora E van Leeuwen³⁰, Rutger van Petersen⁸, W M Monique Verschuren^{8

33}, Frank Visseren³⁴, Roel Vermeulen²¹, Joost Dekker^{35

36}

Affiliations

¹ Department of Internal Medicine, Maasstad Hospital, Rotterdam, The Netherlands.
² Department of Internal Medicine, Division of Medical Oncology, GROW, Maastricht University Medical Centre, Maastricht, The Netherlands.
³ Department of Epidemiology, GROW, Maastricht University, Maastricht, The Netherlands.
⁴ Department of Research, Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, The Netherlands.
⁵ Department of Medical Oncology, Cancer Center University Medical Center, University of Utrecht, Utrecht, The Netherlands.
⁶ Amsterdam UMC, Department of Psychiatry, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands.
⁷ GGZ inGeest Specialized Mental Health Care, Amsterdam, The Netherlands.
⁸ Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.
⁹ Department of Behavioural Science and Health, University College London, London, UK.
¹⁰ Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
¹¹ Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
¹² Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
¹³ Faculty of Nursing and Health Sciences, Nord University, Bodø, Norway.
¹⁴ Faculty of Medicine and Health Sciences, Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.
¹⁵ Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK.
¹⁶ Atlantic Partnership for Tomorrow's Health, Faculty of Health, Dalhousie University, Halifax, Nova Scotia, Canada.
¹⁷ Department of Public and Occupational Health, Amsterdam UMC, and Amsterdam Public Health Research Institute, University of Amsterdam, Amsterdam, Netherlands.
¹⁸ Department of Mathematics, Wilfrid Laurier University, Waterloo, Canada.
¹⁹ Amsterdam UMC, Department of Epidemiology & Data Science, Amsterdam Public Health institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
²⁰ Department of Sociology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
²¹ Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
²² School of Health and Human Performance, Faculty of Health, Dalhousie University, Halifax, Canada.
²³ Department of Epidemiology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
²⁴ Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
²⁵ CARTaGENE, CHU Sainte-Justine, 3175, Chemin de la Côte-Sainte-Catherine, Montréal, Québec, Canada.
²⁶ Department of Developmental Psychology, University of Groningen, Groningen, The Netherlands.
²⁷ Departments of Psychiatry and Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
²⁸ Department of Internal Medicine, Maasstad, Rotterdam, The Netherlands.
²⁹ Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
³⁰ Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
³¹ Department of Public Health and Nursing, HUNT Research Centre, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
³² Levanger hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.
³³ Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment, Utrecht, the Netherlands.
³⁴ Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
³⁵ Amsterdam Public Health Research Institute, Amsterdam, Noord-Holland, The Netherlands.
³⁶ Department of Rehabilitation Medicine and Department of Psychiatry, Amsterdam UMC - VUMC, Amsterdam, Noord-Holland, The Netherlands.

PMID: 34473425
PMCID: PMC8553309
DOI: 10.1002/brb3.2340

Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Lonneke A van Tuijl et al. Brain Behav. 2021 Oct.

. 2021 Oct;11(10):e2340.

doi: 10.1002/brb3.2340. Epub 2021 Sep 2.

Authors

Affiliations

¹ Department of Internal Medicine, Maasstad Hospital, Rotterdam, The Netherlands.
² Department of Internal Medicine, Division of Medical Oncology, GROW, Maastricht University Medical Centre, Maastricht, The Netherlands.
³ Department of Epidemiology, GROW, Maastricht University, Maastricht, The Netherlands.
⁴ Department of Research, Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, The Netherlands.
⁵ Department of Medical Oncology, Cancer Center University Medical Center, University of Utrecht, Utrecht, The Netherlands.
⁶ Amsterdam UMC, Department of Psychiatry, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands.
⁷ GGZ inGeest Specialized Mental Health Care, Amsterdam, The Netherlands.
⁸ Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands.
⁹ Department of Behavioural Science and Health, University College London, London, UK.
¹⁰ Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
¹¹ Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
¹² Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
¹³ Faculty of Nursing and Health Sciences, Nord University, Bodø, Norway.
¹⁴ Faculty of Medicine and Health Sciences, Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.
¹⁵ Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK.
¹⁶ Atlantic Partnership for Tomorrow's Health, Faculty of Health, Dalhousie University, Halifax, Nova Scotia, Canada.
¹⁷ Department of Public and Occupational Health, Amsterdam UMC, and Amsterdam Public Health Research Institute, University of Amsterdam, Amsterdam, Netherlands.
¹⁸ Department of Mathematics, Wilfrid Laurier University, Waterloo, Canada.
¹⁹ Amsterdam UMC, Department of Epidemiology & Data Science, Amsterdam Public Health institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
²⁰ Department of Sociology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
²¹ Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
²² School of Health and Human Performance, Faculty of Health, Dalhousie University, Halifax, Canada.
²³ Department of Epidemiology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
²⁴ Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
²⁵ CARTaGENE, CHU Sainte-Justine, 3175, Chemin de la Côte-Sainte-Catherine, Montréal, Québec, Canada.
²⁶ Department of Developmental Psychology, University of Groningen, Groningen, The Netherlands.
²⁷ Departments of Psychiatry and Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
²⁸ Department of Internal Medicine, Maasstad, Rotterdam, The Netherlands.
²⁹ Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
³⁰ Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
³¹ Department of Public Health and Nursing, HUNT Research Centre, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
³² Levanger hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.
³³ Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment, Utrecht, the Netherlands.
³⁴ Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
³⁵ Amsterdam Public Health Research Institute, Amsterdam, Noord-Holland, The Netherlands.
³⁶ Department of Rehabilitation Medicine and Department of Psychiatry, Amsterdam UMC - VUMC, Amsterdam, Noord-Holland, The Netherlands.

PMID: 34473425
PMCID: PMC8553309
DOI: 10.1002/brb3.2340

Abstract

Objectives: Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer.

Methods: The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2).

Conclusion: PSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses.

Keywords: cancer risk; depression; health behaviors; meta-analysis; psycho-oncology.

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Conflict of interest statement

The authors declare no conflict of interests.

Figures

**FIGURE 1**
The three models that are researched in psychosocial factors and cancer incidence (PSY‐CA): (1) the longitudinal association between psychosocial factors and cancer incidence, (2) the interaction between psychosocial factors and health behaviors, somatic factors, and demographic factors in cancer incidence, and (3) the mediating role of health behaviors in the longitudinal association between psychosocial factors and cancer incidence

See this image and copyright information in PMC

References

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Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Affiliations

Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical