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. 1987;28(2):201-8.
doi: 10.1186/BF03548243.

The interaction of cadmium and selenium in horse kidney cortex in relation to histopathological changes

M Junnila, H Korkeala, T Rahko, A Salmi

The interaction of cadmium and selenium in horse kidney cortex in relation to histopathological changes

M Junnila et al. Acta Vet Scand. 1987.

Abstract
in English, German

The kidney cortex of 32 Finnish horses was analysed chemically for cadmium (Cd) and selenium (Se) content and by light microscopy for histopathological changes of the tissues. Cd concentrations in kidney cortex ranged from 6.9 to 91.6 mg/kg wet weight with an average of 31.9 mg/kg. Se concentrations ranged from 0.5 to 1.5 mg/kg with an average of 1.0 mg/kg. The age of the horses varied from 1.5 to 32 years; mean age was 16 years.

Cd levels in kidney cortex seemed to increase linearly up to an age of about 16 years. In old (over 16 years) horses no such correlation could be found. Se concentrations were found to decrease in relation to age. The horses with higher than 1 mg/kg Se in kidney cortex had less PAS-positive casts than horses with low Se content. Among the total population of the horses no correlation could be demonstrated between Cd and Se concentrations in kidney cortex. However, the horses with more than 40 mg/kg Cd in their kidney cortex had a slightly positive correlation between Cd and Se concentrations.

Njurbarken hos 32 finska hästar analyserades med kemiska metoder rörande förekomsten av kadmium (Cd) och selen (Se) och med ljusmikroskopiska metoder rörande histopatologiska förändringar. Cd-koncentrationen i njurbarken varierade från 6.9 till 91.6 mg/kg våtvikt med ett medelvärde av 31.9 mg/kg. Se-koncentrationen varierade från 0.5 till 1.5 mg/kg med et medelvärde av 1.0 mg/kg. Hästarnas ålder varierade från 1.5 till 32 år, genomsnittsåldern var 16 år.

Cd-halten föreföll att öka jämnt till 16 års ålder men hos gamla (över 16 år) hästar kunde ingen sådan korrelation påvisas. Se-koncentrationen minskade i relation til åldern. PAS-positiva ackumulationer förekom, lägre grad hos hästarna med hög (över 1 mg/kg) Se-koncentration än hos hästarna med låg Se-halt, I hela hästmaterialet kunde ingen korrelation påvisas mellan koncentrationerna av Cd och Se. Hästarna med mera än 40 mg/kg Cd i njurbarken visade en svag positiv korrelation mellan koncentrationerna av Cd och Se.

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