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Review
. 2021 Jul;14(7):1774-1783.
doi: 10.14202/vetworld.2021.1774-1783. Epub 2021 Jul 7.

Development of rat metabolic syndrome models: A review

Shirly Gunawan  1   2 , Ahmad Aulia  3 , Vivian Soetikno  4
Affiliations
Review

Development of rat metabolic syndrome models: A review

Shirly Gunawan et al. Vet World. 2021 Jul.

Abstract

Metabolic syndrome (MetS) has become a global problem. With the increasing prevalence of MetS worldwide, understanding its pathogenesis and treatment modalities are essential. Animal models should allow an appropriate representation of the clinical manifestations of human conditions. Rats are the most commonly used experimental animals for the study. The development of a proper MetS model using rats will contribute to the successful application of research findings to the clinical setting. Various intervention methods are used to induce MetS through diet induction with various compositions, chemicals, or a combination of both. This review will provide a comprehensive overview of several studies on the development of rat MetS models, along with the characteristics of the clinical manifestations resulting from each study.

Keywords: high-fat diet; high-fructose diet; high-sucrose diet; metabolic syndrome; rat models.

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Figures

Figure-1
Figure-1
The pathways of glucose metabolism [12].
Figure-2
Figure-2
The pathways of fructose metabolism [19].
Figure-3
Figure-3
The pathways of lipid metabolism [37].
Figure-4
Figure-4
Interaction between high salt diet and endogenous fructose generation [46].
Figure-5
Figure-5
Effects of glucocorticoid on body metabolism [48].
See this image and copyright information in PMC

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