Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Aug;25(7-8):543-61.
doi: 10.1007/BF00554356.

High activity of an unstable form of glucose phosphate isomerase in the mouse

J D West  1 , R Leask, J H Flockhart, G Fisher
Affiliations

High activity of an unstable form of glucose phosphate isomerase in the mouse

J D West et al. Biochem Genet. 1987 Aug.

Abstract

Quantitative electrophoretic studies of the three allozymes of glucose phosphate isomerase (GPI-1) produced by Gpi-1sa/Gpi-1sc heterozygous mice revealed two opposing influences on GPI-1 activity. First, the GPI-1AC heterodimer is less stable than GPI-1AA but more stable than the GPI-1CC homodimer. Second, a genetic determinant that maps close to or within the Gpi-1s structural gene causes elevated activity of GPI-1AC and probably also GPI-1CC dimers. The relative lability of these allozymes masks this elevated activity in some tissues but the effect is probably ubiquitous. The significance of these observations is discussed.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • Mouse chromosome 7.
    Rinchik EM, Saunders AM, Holdener-Kenny B, Sutcliffe MJ, Brown KA, Brown SD, Peters J. Rinchik EM, et al. Mamm Genome. 1991;1 Spec No:S97-111. doi: 10.1007/BF00656488. Mamm Genome. 1991. PMID: 1799814 Review. No abstract available.
  • Mouse chromosome 7.
    Rinchik EM, Magnuson T, Holdener-Kenny B, Kelsey G, Bianchi A, Conti CJ, Chartier F, Brown KA, Brown SD, Peters J. Rinchik EM, et al. Mamm Genome. 1992;3 Spec No:S104-20. doi: 10.1007/BF00648425. Mamm Genome. 1992. PMID: 1498426 Review. No abstract available.

References

    1. Proc Natl Acad Sci U S A. 1983 Jul;80(14):4398-402 - PubMed
    1. J Embryol Exp Morphol. 1986 Sep;97:225-37 - PubMed
    1. Biochem Genet. 1969 Apr;3(2):151-62 - PubMed
    1. Cell. 1977 Dec;12(4):873-82 - PubMed
    1. Nature. 1967 Nov 4;216(5114):511 - PubMed

Publication types

Substances

LinkOut - more resources