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Comment
. 2021 Sep 2;28(9):1505-1506.
doi: 10.1016/j.stem.2021.08.008.

Inflation comes before the fall: How epithelial stretch drives crypt fission

Geraldine M Jowett  1 , Eileen Gentleman  2
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Inflation comes before the fall: How epithelial stretch drives crypt fission

Geraldine M Jowett et al. Cell Stem Cell. .
Free article

Abstract

In this issue of Cell Stem Cell, Tallapragada et al. (2021) present an intestinal organoid culture system for high-throughput live imaging to investigate niche-independent mechanisms of crypt fission. They find that Piezo activity downregulates Lgr5 expression in stretched epithelial cells within inflated organoids, which form multiple new crypts upon collapse.

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