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Comment
. 2021 Sep 2;81(17):3445-3446.
doi: 10.1016/j.molcel.2021.08.013.

Exploiting a key transcriptional dependency: ZMYND8 and IRF8 in AML

Samuel J Taylor  1 , Sriram Sundaravel  1 , Ulrich Steidl  2
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Comment

Exploiting a key transcriptional dependency: ZMYND8 and IRF8 in AML

Samuel J Taylor et al. Mol Cell. .
Free article

Abstract

In this issue of Molecular Cell, Cao et al. (2021) report that AML cells are specifically addicted to an IRF8-MEF2D gene expression network. Furthermore, they identify a chromatin reader, ZMYND8, as the upstream regulator of the IRF8-MEF2D program whose activity is critical for AML cell survival.

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  • ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency.
    Cao Z, Budinich KA, Huang H, Ren D, Lu B, Zhang Z, Chen Q, Zhou Y, Huang YH, Alikarami F, Kingsley MC, Lenard AK, Wakabayashi A, Khandros E, Bailis W, Qi J, Carroll MP, Blobel GA, Faryabi RB, Bernt KM, Berger SL, Shi J. Cao Z, et al. Mol Cell. 2021 Sep 2;81(17):3604-3622.e10. doi: 10.1016/j.molcel.2021.07.018. Epub 2021 Aug 5. Mol Cell. 2021. PMID: 34358447 Free PMC article.

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