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Comment
. 2021 Sep 2;81(17):3447-3448.
doi: 10.1016/j.molcel.2021.08.014.

A small nucleosome from a weird virus with a fat genome

Alessandro Vannini  1 , Ivan Marazzi  2
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A small nucleosome from a weird virus with a fat genome

Alessandro Vannini et al. Mol Cell. .
Free article

Abstract

Valencia-Sánchez et al. (2021) and Liu et al. (2021) provide structural and biological insights about the existence and importance of a nucleosome-like particle in a family of giant viruses.

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  • The structure of a virus-encoded nucleosome.
    Valencia-Sánchez MI, Abini-Agbomson S, Wang M, Lee R, Vasilyev N, Zhang J, De Ioannes P, La Scola B, Talbert P, Henikoff S, Nudler E, Erives A, Armache KJ. Valencia-Sánchez MI, et al. Nat Struct Mol Biol. 2021 May;28(5):413-417. doi: 10.1038/s41594-021-00585-7. Epub 2021 Apr 29. Nat Struct Mol Biol. 2021. PMID: 33927388 Free PMC article.
  • Virus-encoded histone doublets are essential and form nucleosome-like structures.
    Liu Y, Bisio H, Toner CM, Jeudy S, Philippe N, Zhou K, Bowerman S, White A, Edwards G, Abergel C, Luger K. Liu Y, et al. Cell. 2021 Aug 5;184(16):4237-4250.e19. doi: 10.1016/j.cell.2021.06.032. Epub 2021 Jul 22. Cell. 2021. PMID: 34297924 Free PMC article.

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