Moving towards a Treatable Traits model of care for the management of obstructive airways diseases

Affiliations

¹ Cátedra Salud Respiratoria University of Barcelona, Respiratory Institute Hospital Clinic Barcelona, IDIBAPS Barcelona, and CIBERES, Barcelona, Spain. Electronic address: AAGUSTI@clinic.cat.
² Respiratory Medical Franchise, GSK, Brentford, UK; The William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK.
³ Fundação ProAR and Universidade Federal da Bahia, Salvador, Brazil.
⁴ Priority Research Centre for Healthy Lungs and Hunter Medical Research Institute, Faculty of Health and Medicine, The University of Newcastle, Callaghan, New South Wales, Australia.
⁵ Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
⁶ Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
⁷ Pulmonary and Critical Care Medicine Division, New York-Presbyterian Weill Cornell Medical Center, New York, NY, USA.
⁸ Department of Internal Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.
⁹ Respiratory Medicine, Department of Translational Medicine, University of Ferrara, Ferrara, Italy.
¹⁰ Respiratory Medicine Unit and NIHR Oxford Respiratory BRC, Nuffield Dept of Medicine, University of Oxford, Oxford, UK.
¹¹ Primary Care Research Centre, School of Primary Care, Population Sciences and Medical Education, University of Southampton, Southampton, UK.
¹² Asthma UK and British Lung Foundation Partnership, London, UK.

PMID: 34478992
DOI: 10.1016/j.rmed.2021.106572

Free article

Review

Moving towards a Treatable Traits model of care for the management of obstructive airways diseases

Alvar Agusti et al. Respir Med. 2021 Oct.

Free article

. 2021 Oct:187:106572.

doi: 10.1016/j.rmed.2021.106572. Epub 2021 Aug 13.

Authors

Affiliations

¹ Cátedra Salud Respiratoria University of Barcelona, Respiratory Institute Hospital Clinic Barcelona, IDIBAPS Barcelona, and CIBERES, Barcelona, Spain. Electronic address: AAGUSTI@clinic.cat.
² Respiratory Medical Franchise, GSK, Brentford, UK; The William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK.
³ Fundação ProAR and Universidade Federal da Bahia, Salvador, Brazil.
⁴ Priority Research Centre for Healthy Lungs and Hunter Medical Research Institute, Faculty of Health and Medicine, The University of Newcastle, Callaghan, New South Wales, Australia.
⁵ Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK.
⁶ Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
⁷ Pulmonary and Critical Care Medicine Division, New York-Presbyterian Weill Cornell Medical Center, New York, NY, USA.
⁸ Department of Internal Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.
⁹ Respiratory Medicine, Department of Translational Medicine, University of Ferrara, Ferrara, Italy.
¹⁰ Respiratory Medicine Unit and NIHR Oxford Respiratory BRC, Nuffield Dept of Medicine, University of Oxford, Oxford, UK.
¹¹ Primary Care Research Centre, School of Primary Care, Population Sciences and Medical Education, University of Southampton, Southampton, UK.
¹² Asthma UK and British Lung Foundation Partnership, London, UK.

PMID: 34478992
DOI: 10.1016/j.rmed.2021.106572

Abstract

Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic airways diseases. Both are complex and heterogeneous. Traditionally, clinical guidelines have advocated a stepwise approach to pharmacotherapy of asthma and COPD, but there is increasing realization that both require a more personalized and precise management approach. To this end, a management strategy based on the so-called Treatable Traits has been proposed. Emerging evidence suggests that this model improves relevant outcomes in patients with chronic airway diseases but further research is needed to guide implementation. This review discusses the challenges, opportunities, and hurdles that its implementation will have to face.

Keywords: Asthma; Biomarkers; COPD; Targeted therapy.

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Moving towards a Treatable Traits model of care for the management of obstructive airways diseases

Affiliations

Moving towards a Treatable Traits model of care for the management of obstructive airways diseases

Authors

Affiliations

Abstract

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical