Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Sep 3;21(1):904.
doi: 10.1186/s12879-021-06627-1.

Clinical feature of severe fever with thrombocytopenia syndrome (SFTS)-associated encephalitis/encephalopathy: a retrospective study

Ying Xu  1 , Mingran Shao  2 , Ning Liu  1 , Danjiang Dong  1 , Jian Tang  1 , Qin Gu  3
Affiliations

Clinical feature of severe fever with thrombocytopenia syndrome (SFTS)-associated encephalitis/encephalopathy: a retrospective study

Ying Xu et al. BMC Infect Dis. .

Abstract

Background/objective: Severe fever with thrombocytopenia syndrome (SFTS) cause encephalitis/encephalopathy, but few reports were available. We aimed to investigate the incidence of encephalitis/encephalopathy in SFTS patients and to summarize clinical characteristics, laboratory findings and imaging features.

Methods: We conducted a retrospective review of all patients with confirmed SFTS admitted to Nanjing Drum Tower Hospital, a tertiary hospital in Nanjing City, China, between January 2016 and July 2020. The patients were divided into two groups according to whether they had encephalitis/encephalopathy: encephalitis/encephalopathy group and non- encephalitis/encephalopathy group. Clinical data, laboratory findings, imaging characteristics, treatments and outcomes of these patients were collected and analyzed.

Results: A total of 109 SFTS patients with were included, of whom 30 (27.5 %) developed encephalitis/encephalopathy. In-hospital mortality (43.3 %) was higher in encephalitis/encephalopathy group than non-encephalitis/encephalopathy group (12.7 %). Univariate logistic regression showed that cough, wheezing, dyspnoea, respiratory failure, vasopressors use, bacteremia, invasive pulmonary aspergillosis (IPA) diagnoses, PCT > 0.5 ug/L, CRP > 8 mg/L, AST > 200 U/L and serum amylase level > 80 U/L were the risk factors for the development of encephalitis/encephalopathy for SFTS patients. Multivariate logistic regression analysis identified bacteremia, PCT > 0.5 mg/L and serum amylase level > 80 U/L as independent predictors of encephalitis/ encephalopathy development for SFTS patients.

Conclusions: SFTS-associated encephalitis/encephalopathy has high morbidity and mortality. it was necessary to strengthen the screening of CSF testing and brain imaging after admission for SFTS patients who had symptoms of encephalitis/encephalopathy. SFTS patients with bacteremia, PCT > 0.5 ug/L or serum amylase level > 80 U/L should be warned to progress to encephalopathy.

Keywords: Amylase; Bacteremia; Cerebrospinal fluid; Encephalitis; Encephalopathy; Severe fever with thrombocytopenia syndrome; Vasopressor.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Schematic flow chart of patient enrolment. SFTS severe fever with thrombocytopenia syndrome, CSF cerebrospinal fluid
Fig. 2
Fig. 2
A Brain MRI showed patchy mixed signal shadows in the left occipital lobe, with a diameter of approximately 3.9 cm. B, C Short T1 signal shadows were visible, and patchy enhancement was observed. Multiple patchy slightly longer T2 signal shadows can be seen in both cerebral hemispheres. DWI phase shows high signal intensity, surrounding areas of oedema, and enhanced patchy enhancement
See this image and copyright information in PMC

References

    1. Yu XJ, Liang MF, Zhang SY, et al. Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med. 2011;21(16):1523–1532. doi: 10.1056/NEJMoa1010095. - DOI - PMC - PubMed
    1. Kim WY, Choi W, Park SW, et al. Nosocomial transmission of severe fever with thrombocytopenia syndrome in Korea. Clin Infect Dis. 2015;1(11):1681–1683. doi: 10.1093/cid/civ128. - DOI - PubMed
    1. Kobayashi Y, Kato H, Yamagishi T, et al. Severe fever with thrombocytopenia syndrome, Japan, 2013–2017. Emerg Infect Dis. 2020;26(4):692–699. doi: 10.3201/eid2604.191011. - DOI - PMC - PubMed
    1. Tran XC, Yun Y, Van An L, et al. Endemic Severe Fever with Thrombocytopenia Syndrome, Vietnam. Emerg Infect Dis. 2019;25(5):1029–1031. doi: 10.3201/eid2505.181463. - DOI - PMC - PubMed
    1. Lin TL, Ou SC, Maeda K, et al. The first discovery of severe fever with thrombocytopenia syndrome virus in Taiwan. Emerg Microbes Infect. 2020;9(1):148–151. doi: 10.1080/22221751.2019.1710436. - DOI - PMC - PubMed