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Comment
. 2021 Oct;42(10):841-843.
doi: 10.1016/j.it.2021.08.007. Epub 2021 Aug 31.

Runner's niche: multipurpose stromal cells maintained by exercise

Nikolaus Dietlein  1 , Hans-Reimer Rodewald  2
Affiliations
Comment

Runner's niche: multipurpose stromal cells maintained by exercise

Nikolaus Dietlein et al. Trends Immunol. 2021 Oct.

Abstract

Using newly developed reporter and lineage-tracing mice, Shen et al. found perivascular stromal cells coexpressing osteolectin and leptin receptor in the bone marrow that specifically supported lymphoid progenitors, served as osteoblast progenitors, and were maintained by mechanical stimulation. Exercise may thus have joint positive influences on lymphopoiesis and bone formation.

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Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest.

Comment on

  • A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis.
    Shen B, Tasdogan A, Ubellacker JM, Zhang J, Nosyreva ED, Du L, Murphy MM, Hu S, Yi Y, Kara N, Liu X, Guela S, Jia Y, Ramesh V, Embree C, Mitchell EC, Zhao YC, Ju LA, Hu Z, Crane GM, Zhao Z, Syeda R, Morrison SJ. Shen B, et al. Nature. 2021 Mar;591(7850):438-444. doi: 10.1038/s41586-021-03298-5. Epub 2021 Feb 24. Nature. 2021. PMID: 33627868 Free PMC article.

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