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Comment
. 2021 Oct;42(10):844-845.
doi: 10.1016/j.it.2021.08.010. Epub 2021 Sep 1.

Trust your gut: an early life lesson for T cells

Jennifer E Cowan  1
Affiliations
Comment

Trust your gut: an early life lesson for T cells

Jennifer E Cowan. Trends Immunol. 2021 Oct.

Abstract

Zegarra-Ruiz et al. demonstrate that gut microbe-specific T cells are selected within the thymus exclusively during early life in mice. This selection is dependent on CX3CR1+ dendritic cells migrating from the gut carrying bacterially derived antigens into the thymus. This offers new insight into how gut microbiota influence T cell development.

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Conflict of interest statement

Declaration of interests No interests are declared.

Comment on

  • Thymic development of gut-microbiota-specific T cells.
    Zegarra-Ruiz DF, Kim DV, Norwood K, Kim M, Wu WH, Saldana-Morales FB, Hill AA, Majumdar S, Orozco S, Bell R, Round JL, Longman RS, Egawa T, Bettini ML, Diehl GE. Zegarra-Ruiz DF, et al. Nature. 2021 Jun;594(7863):413-417. doi: 10.1038/s41586-021-03531-1. Epub 2021 May 12. Nature. 2021. PMID: 33981034 Free PMC article.

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