Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 Sep 3;14(9):e242907.
doi: 10.1136/bcr-2021-242907.

Oesophagomediastinal fistula: a rare complication of tuberculosis

Affiliations
Case Reports

Oesophagomediastinal fistula: a rare complication of tuberculosis

Maurizio Nedkov Gambin et al. BMJ Case Rep. .

Abstract

We report a case of a woman from Thailand, living in Malta, who was diagnosed with concomitant tuberculosis (TB) and HIV with depleted CD4 count. Her case was further complicated by the formation of a fistula between the mediastinal lymph nodes and the oesophagus, an unusual finding but for which she had many risk factors. The diagnosis was suspected on CT scan of the thorax and confirmed via upper gastrointestinal endoscopy. Following the commencement of both anti-TB and antiretroviral therapy, she suffered a lapse of immune reconstitution inflammatory syndrome but with aggressive medical management eventually made a full recovery without the need for surgical intervention.

Keywords: HIV / AIDS; TB and other respiratory infections; oesophagus.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
CT thorax showing subcarinal lymphadenopathy (white arrow).
Figure 2
Figure 2
CT thorax showing the oesophagus (a) and the oesophagomediastinal fistula (b).
Figure 3
Figure 3
There is a horseshoe-shaped defect and caseous material seen at the fistulous opening.
Figure 4
Figure 4
CT thorax showing resolution of mediastinal lymphadenopathy and oesophagomediastinal fistula.

References

    1. Santamaría AZ, Vallejo VG, Gómez PC. Oesophageal fistula due to tuberculosis in HIV patients: report of two cases. Rev Colomb Radiol 2016;28:4630–5.
    1. Rämö OJ, Salo JA, Isolauri J, et al. . Tuberculous fistula of the esophagus. Ann Thorac Surg 1996;62:1030–2. 10.1016/0003-4975(96)00471-7 - DOI - PubMed
    1. Devarbhavi HC, Alvares JF, Radhikadevi M. Esophageal tuberculosis associated with esophagotracheal or esophagomediastinal fistula: report of 10 cases. Gastrointest Endosc 2003;57:588–92. 10.1067/mge.2003.140 - DOI - PubMed
    1. Sasikumar C, Utpat K, Desai U, et al. . “Esophagomediastinal fistula presenting as drug resistant tuberculosis”. Indian J Tuberc 2020;67:363–5. 10.1016/j.ijtb.2019.08.007 - DOI - PubMed
    1. de Silva R, Stoopack PM, Raufman JP. Esophageal fistulas associated with mycobacterial infection in patients at risk for AIDS. Radiology 1990;175:449–53. 10.1148/radiology.175.2.2326472 - DOI - PubMed

Publication types