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Comment
. 2021 Sep;11(9):2132-2134.
doi: 10.1158/2159-8290.CD-21-0861.

Spatiofunctional Dynamics of NKX3.1 to Safeguard the Prostate from Cancer

Andrew J Finch  1 , Esther Baena  2   3
Affiliations
Comment

Spatiofunctional Dynamics of NKX3.1 to Safeguard the Prostate from Cancer

Andrew J Finch et al. Cancer Discov. 2021 Sep.

Abstract

A novel role of NKX3.1 in the mitochondria regulating the transcription of the electron transport chain components is reported. Mechanistically, HSPA9 chaperones NKX3.1 into the mitochondria in response to oxidative stress to regulate reactive oxygen species and suppress tumor initiation.See related article by Papachristodoulou et al., p. 2316.

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Comment on

  • NKX3.1 Localization to Mitochondria Suppresses Prostate Cancer Initiation.
    Papachristodoulou A, Rodriguez-Calero A, Panja S, Margolskee E, Virk RK, Milner TA, Martina LP, Kim JY, Di Bernardo M, Williams AB, Maliza EA, Caputo JM, Haas C, Wang V, De Castro GJ, Wenske S, Hibshoosh H, McKiernan JM, Shen MM, Rubin MA, Mitrofanova A, Dutta A, Abate-Shen C. Papachristodoulou A, et al. Cancer Discov. 2021 Sep;11(9):2316-2333. doi: 10.1158/2159-8290.CD-20-1765. Epub 2021 Apr 23. Cancer Discov. 2021. PMID: 33893149 Free PMC article.

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