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. 2022 Jan;59(1):69-81.
doi: 10.1007/s00592-021-01787-7. Epub 2021 Sep 3.

Nutrigenetic variants and response to diet/lifestyle intervention in obese subjects: a pilot study

Marica Franzago  1   2 , Marta Di Nicola  3 , Federica Fraticelli  1 , Michele Marchioni  3 , Liborio Stuppia  2   4 , Ester Vitacolonna  5   6
Affiliations

Nutrigenetic variants and response to diet/lifestyle intervention in obese subjects: a pilot study

Marica Franzago et al. Acta Diabetol. 2022 Jan.

Abstract

Aims: Nutritional and lifestyle interventions can contribute to prevent and treat obesity and its complications; however, genetic background may influence the success of a therapy. The aim of this pilot study is to evaluate the effects of the interaction between nutrigenetic variants and nutritional intervention, as well as the changes in clinical parameters and the adherence to Mediterranean diet (MedDiet) and to physical activity, of 18 overweight or obese subjects affected by T2D or dysglycemia included in a nutritional program.

Methods: The subjects' clinical parameters as well as their PREDIMED score and physical activity levels were recorded and compared at baseline, at 6 months and at the end of the intervention. Rs9939609 in FTO, rs17782313 near MC4R, rs326 in LPL, rs16147 in NPY, rs2943641 near IRS-1 were genotyped.

Results: The subjects carrying the A allele in FTO lost less weight (p = 0.022) and had a lower BMI decrease from baseline to 12 months (p-interaction = 0.047) than TT carriers. In addition, there was a significant PREDIMED score modification over time, according to genotypes for FTO rs9939609 (p = 0.025) and NPY rs16147 (p = 0.039), respectively.

Conclusions: These preliminary findings show a significant interaction between genetic variants and the PREDIMED score, suggesting that individuals carrying the FTO variant may lose less weight than non-carriers through diet/lifestyle intervention.

Keywords: FTO; Gene–diet interaction; Mediterranean diet; Nutrigenetics; Nutrition; Obesity; Rs9939609; Type 2 diabetes.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Frequencies of genetic variants according to additive genetic model
Fig. 2
Fig. 2
Frequencies of genetic variants according to dominant genetic model
Fig. 3
Fig. 3
Frequencies of genetic variants according to recessive genetic model
See this image and copyright information in PMC

Comment in

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