Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Dec;9(12):1349-1351.
doi: 10.1016/S2213-2600(21)00358-1. Epub 2021 Sep 1.

Baricitinib: the first immunomodulatory treatment to reduce COVID-19 mortality in a placebo-controlled trial

Affiliations
Comment

Baricitinib: the first immunomodulatory treatment to reduce COVID-19 mortality in a placebo-controlled trial

Andre C Kalil et al. Lancet Respir Med. 2021 Dec.
No abstract available

PubMed Disclaimer

Conflict of interest statement

JS reports personal fees from Vaccitech, Heat Biologics, Eli Lilly, Alveo Technologies, Agenus, Equilibre Biopharmaceuticals, Graviton Bioscience Corporation, Greenmantle, Zedsen, BenevolentAI, Lansdowne Partners, Vitruvian, BB Healthcare Trust PLC, and Celltrion; lecture fees from Eli Lilly; and advisory board participation (without fees) for Pear Bio, Certis Oncology Solutions, Bryologyx, the College of Experts for the DHSC/UKRI Global Effect on COVID-19 Health Research funding opportunity, and Volvox, all outside of the submitted work. JS is also on the board of directors for Xerion (without fees); and is the co-editor-in-chief of Oncogene (with stipend received from Springer Nature), outside of the submitted work. ACK declares no competing interests.

Comment on

References

    1. Kalil AC, Johnson DW, Lisco SJ, Sun J. Early goal-directed therapy for sepsis: a novel solution for discordant survival outcomes in clinical trials. Crit Care Med. 2017;45:607–614. - PubMed
    1. Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) JAMA. 2016;315:801–810. - PMC - PubMed
    1. Kalil AC, Syed A, Rupp ME, et al. Is bacteremic sepsis associated with higher mortality in transplant recipients than in nontransplant patients? A matched case-control propensity-adjusted study. Clin Infect Dis. 2015;60:216–222. - PubMed
    1. Donnelly JP, Locke JE, MacLennan PA, et al. Inpatient mortality among solid organ transplant recipients hospitalized for sepsis and severe sepsis. Clin Infect Dis. 2016;63:186–194. - PMC - PubMed
    1. Beigel JH, Tomashek KM, Dodd LE, et al. Remdesivir for the treatment of COVID-19—final report. N Engl J Med. 2020;383:1813–1826. - PMC - PubMed