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. 2022 Jun;18(6):1177-1185.
doi: 10.1002/alz.12448. Epub 2021 Sep 5.

Transition from mild cognitive impairment to normal cognition: Determining the predictors of reversion with multi-state Markov models

Rubén Sanz-Blasco  1 , José M Ruiz-Sánchez de León  1 , Marina Ávila-Villanueva  2 , Meritxel Valentí-Soler  2 , Jaime Gómez-Ramírez  3 , Miguel A Fernández-Blázquez  1
Affiliations

Transition from mild cognitive impairment to normal cognition: Determining the predictors of reversion with multi-state Markov models

Rubén Sanz-Blasco et al. Alzheimers Dement. 2022 Jun.

Abstract

Introduction: The theoretical framework of the Alzheimer's disease continuum considers transition between stages in a unidirectional manner. Here we examine the rate of reversion from mild cognitive impairment (MCI) to normal cognition (NC) and explore a set of potential variables associated with this phenomenon.

Methods: A total of 985 Spanish community-dwelling individuals aged 70 years and over at baseline were monitored for 5 years. During this time, 173 MCI and 36 dementia cases were identified. Multi-state Markov models were performed to characterize transitions between states through the dementia continuum.

Results: The rate of reversion from MCI to NC was 11%. There were significant non-modifiable (age, socioeconomic status, or apolipoprotein E) and modifiable factors (cognitive training or absence of affective symptoms) associated with reversion.

Discussion: Overall, our results highlight that the likelihood of progression from MCI to dementia is very similar to that of reversion from MCI to NC.

Keywords: Alzheimer´s disease; dementia; mild cognitive impairment; multi-state Markov model; normal cognition; subjective cognitive decline.

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References

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