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Case Reports
. 2022 Mar 15;61(6):861-864.
doi: 10.2169/internalmedicine.7915-21. Epub 2021 Sep 4.

Persistent Hypoglycemia Induced by Long-acting Insulin Degludec

Yukino Katakura  1 , Fuminori Tatsumi  1 , Takashi Kusano  1 , Masashi Shimoda  1 , Kenji Kohara  1 , Tomohiko Kimura  1 , Atsushi Obata  1 , Shuhei Nakanishi  1 , Tomoatsu Mune  1 , Kohei Kaku  1 , Hideaki Kaneto  1
Affiliations
Case Reports

Persistent Hypoglycemia Induced by Long-acting Insulin Degludec

Yukino Katakura et al. Intern Med. .

Abstract

A 58-year-old Japanese man was brought to the emergency room due to disturbance of consciousness. He regained consciousness on the day of admission and started taking hospital meals, but he needed intravenous glucose administration for eight days. The total amount of glucose administration was 4,464 g. It took over three weeks for exogenous insulin to be almost undetectable. While degludec binds to albumin and exerts glucose-lowering effects for a long time, the above-mentioned period of three weeks was consistent with the half-life of albumin. Hypoglycemia induced by massive dose of insulin degludec is persistent and prominent.

Keywords: a pitfall; diabetes care; insulin degludec; insulin therapy; severe hypoglycemia.

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Conflict of interest statement

The authors state that they have no Conflict of Interest (COI).

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