Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2020 Feb 18:9:119.
doi: 10.12688/f1000research.22256.1. eCollection 2020.

Case Report: Upper airway obstruction due to rheumatoid arthritis

Affiliations
Case Reports

Case Report: Upper airway obstruction due to rheumatoid arthritis

Mohan Rudrappa et al. F1000Res. .

Abstract

Rheumatoid arthritis (RA) is a common autoimmune disease characterized by inflammation of small joints. Small synovial joints in the larynx can also become affected, and laryngeal involvement is seen in more than half of patients with RA. As most patients have subtle symptoms and indolent course, they are either misdiagnosed or undiagnosed. The acute worsening of cricoarytenoid arthritis can cause sudden upper airway obstruction and may require emergency intubation or tracheostomy. This life-threatening condition is described in only a handful of cases in the medical literature. Physicians should be aware of this rare but life-threatening consequence of RA. We present a case of sudden and severe upper airway obstruction secondary to laryngeal involvement in a patient with long-standing RA.

Keywords: Odontoid fracture; Rheumatoid arthritis; Upper airway obstruction; cricoarytenoid joint.

PubMed Disclaimer

Conflict of interest statement

No competing interests were disclosed.

Figures

Figure 1.
Figure 1.. CT scan of the cervical neck showing Type II odontoid fracture (blue arrow) and sclerosis of the arytenoid cartilage (yellow arrow).
Figure 2.
Figure 2.. Video bronchoscopy images showing enlarged arytenoid appendages (yellow arrows).
Endotracheal tube (blue arrow) can be seen entering the vocal cords.

References

    1. Scott DL, Wolfe F, Huizinga TW: Rheumatoid arthritis. Lancet. 2010;376(9746):1094–1108. 10.1016/S0140-6736(10)60826-4 - DOI - PubMed
    1. Greco A, Fusconi M, Macri GF, et al. : Cricoarytenoid joint involvement in rheumatoid arthritis: radiologic evaluation. Am J Otolaryngol. 2012;33(6):753–755. 10.1016/j.amjoto.2012.06.004 - DOI - PubMed
    1. Kolman J, Morris I: Cricoarytenoid arthritis: a cause of acute upper airway obstruction in rheumatoid arthritis. Can J Anaesth. 2002;49(7):729–732. 10.1007/BF03017454 - DOI - PubMed
    1. Hamdan AL, El-Khatib M, Dagher W, et al. : Laryngeal involvement in rheumatoid arthritis. Middle East J Anaesthesiol. 2007;19(2):335–44. - PubMed
    1. Stojanović SP, Zivić L, Stojanović J, et al. : Total fixation of cricoarytenoid joint of a patient with rheumatoid arthritis and Hashimoto thyroiditis. Srp Arh Celok Lek. 2010;138(3–4):230–232. 10.2298/sarh1004230s - DOI - PubMed

Publication types