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Case Reports
. 2021 Aug 27:24:101196.
doi: 10.1016/j.ajoc.2021.101196. eCollection 2021 Dec.

Unilateral retinopathy post perilesional interferon α2b injections for ocular surface squamous cell carcinoma

Shiv Dalla  1 , Mary Champion  2 , Radwan Ajlan  2 , John E Sutphin  2 , Jason A Sokol  2
Affiliations
Case Reports

Unilateral retinopathy post perilesional interferon α2b injections for ocular surface squamous cell carcinoma

Shiv Dalla et al. Am J Ophthalmol Case Rep. .

Abstract

Purpose: To describe the clinical course of a patient presenting with unilateral retinopathy after perilesional interferon alpha injections for treatment of ocular surface squamous cell carcinoma.

Observations: A patient, who was being treated with interferon alpha for ocular squamous cell carcinoma, presented with new onset decreased vision in her left eye. Upon examination, she was found to have cotton wool spots and retinal hemorrhages in the affected eye.

Conclusions and importance: Retinopathy is a well-documented side effect of systemic usage of interferon alpha. However, retinopathy has not been well discussed in the scenario of perilesional injections of interferon. It is important for clinicians to monitor for such pathology when using interferon alpha not only systemically, but also locally.

Keywords: Interferon α2b; Ocular squamous neoplasia; Retinopathy.

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Figures

Fig. 1
Fig. 1
Fundus photographs of the patient's right (A) and left (B) eye. The right eye (A) appears unaffected. The left eye (B) view is mildly blurred due to corneal dryness, and shows cotton wool spots and small hemorrhages.
Fig. 2
Fig. 2
Fluorescein angiography of the patient's right (A) and left (B) eye. The right eye (A) shows normal filling, however the left eye (B) shows hypofluorescence consistent with the cotton wool spots and hemorrhages seen in Fig. 1.
Fig. 3
Fig. 3
Thickness map taken months after initial presentation of cotton wool spots shows thinning over time, corresponding with the location of the cotton wool spots.
See this image and copyright information in PMC

References

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